Leah C. Katzelnick, Ph.D., M.P.H.
Viral Epidemiology and Immunity Unit
Mosquito-borne flaviviruses infect hundreds of millions of people globally each year and cause a spectrum of life-threatening diseases, including hemorrhagic fevers, encephalitis, and severe congenital abnormalities. There are still no licensed, broadly protective vaccines against two of the most important flaviviruses: dengue virus and Zika virus. Dengue viruses 1-4 are challenging vaccine targets because sub-protective vaccines can increase risk of Dengue Hemorrhagic Fever/Dengue Shock Syndrome, the disease dengue vaccines are designed to prevent. The only licensed dengue vaccine to date significantly increases risk of severe dengue disease in those without a prior dengue virus exposure. Zika viruses emerged across the Americas in 2014-2017, causing major pandemics and congenital Zika syndrome, making development of a Zika vaccine a high priority.
The Viral Epidemiology and Immunity Unit (VEIU) uses a multidisciplinary approach to investigate immunological protection against and susceptibility to emerging and re-emerging viral diseases with the goal of informing how vaccines can be effectively and safely licensed and introduced through vaccination programs. Our work focuses on immunologically complex diseases caused by flaviviruses, including dengue and Zika viruses, as well as coronaviruses. We collaborate with research teams to study determinants of disease in longitudinal cohort and vaccine studies in Nicaragua, Thailand, Ecuador, the Philippines, and other sites. To address questions about virus antigenicity, host protective immunity, and population-level viral transmission dynamics, we use biologically relevant immunological assays and diverse computational and epidemiological methods to measure and evaluate the role of immunity in protection against disease in human cohort studies.
Dr. Leah Katzelnick pursued a Ph.D. studying antigenic variation among dengue viruses at the University of Cambridge and the National Institutes of Health as an NIH OxCam Scholar and Gates Cambridge Scholar. After receiving her Ph.D. in 2016, she conducted her postdoctoral work at the University of California, Berkeley and University of Florida on determinants of dengue and Zika disease, spending a year in Ecuador and Nicaragua to work closely with research teams conducting longitudinal cohort studies. In September of 2020, Leah became an Earl Stadtman tenure-track investigator and NIH Distinguished Scholar in the Laboratory of Infectious Diseases in NIAID. She is Chief of the Viral Epidemiology and Immunity Unit.
- Katzelnick LC, Coello Escoto A, Huang AT, Garcia-Carreras B, Chowdhury N, Maljkovic Berry I, Chavez C, Buchy P, Duong V, Dussart P, Gromowski G, Macareo L, Thaisomboonsuk B, Fernandez S, Smith DJ, Jarman R, Whitehead SS, Salje H, Cummings DAT. Antigenic evolution of dengue viruses over 20 years. Science. 2021;374(6570):999-1004.
- Huang AT, Salje H, Escoto AC, Chowdhury N, Chávez C, Garcia-Carreras B, Rutvisuttinunt W, Maljkovic Berry I, Gromowski GD, Wang L, Klungthong C, Thaisomboonsuk B, Nisalak A, Trimmer-Smith LM, Rodriguez-Barraquer I, Ellison DW, Jones AR, Fernandez S, Thomas SJ, Smith DJ, Jarman R, Whitehead SS, Cummings DAT, Katzelnick LC. Beneath the surface: Amino acid variation underlying two decades of dengue virus antigenic dynamics in Bangkok, Thailand. PLoS Pathog. 2022;18(5):e1010500.
- Katzelnick LC, Zambrana JV, Elizondo D, Collado D, Garcia N, Arguello S, Mercado JC, Miranda T, Ampie O, Mercado BL, Narvaez C, Gresh L, Binder RA, Ojeda S, Sanchez N, Plazaola M, Latta K, Schiller A, Coloma J, Carrillo FB, Narvaez F, Halloran ME, Gordon A, Kuan G, Balmaseda A, Harris E. Dengue and Zika virus infections in children elicit cross-reactive protective and enhancing antibodies that persist long term. Sci Transl Med. 2021;13(614):eabg9478.
- Odio CD, Lowman KE, Law M, Aogo RA, Hunsberger S, Wood BJ, Kassin M, Levy E, Callier V, Firdous S, Hasund CM, Voirin C, Kattappuram R, Yek C, Manning J, Durbin A, Whitehead SS, Katzelnick LC. Phase 1 trial to model primary, secondary, and tertiary dengue using a monovalent vaccine. BMC Infect Dis. 2023;23(1):345.
- Wang W, Lusvarghi S, Subramanian R, Epsi NJ, Wang R, Goguet E, Fries AC, Echegaray F, Vassell R, Coggins SA, Richard SA, Lindholm DA, Mende K, Ewers EC, Larson DT, Colombo RE, Colombo CJ, Joseph JO, Rozman JS, Smith A, Lalani T, Berjohn CM, Maves RC, Jones MU, Mody R, Huprikar N, Livezey J, Saunders D, Hollis-Perry M, Wang G, Ganesan A, Simons MP, Broder CC, Tribble DR, Laing ED, Agan BK, Burgess TH, Mitre E, Pollett SD, Katzelnick LC, Weiss CD. Antigenic cartography of well-characterized human sera shows SARS-CoV-2 neutralization differences based on infection and vaccination history. Cell Host Microbe. 2022;30(12):1745-1758.e7.
Related Scientific Focus Areas
Microbiology and Infectious Diseases
This page was last updated on Saturday, August 19, 2023