The Section on Sensory Cell Development and Function investigates how discrete subcellular signals, such as Ca2+ influx and vesicle release, shape hair cell development, and how these signals are required for proper physiological function. To study hair cell development and function we use the zebrafish as a model system. Similar to mammals, zebrafish have sensory hair cells that enable them to sense sound and maintain proper balance. Previous work has shown that the same genes that cause deafness in zebrafish are associated with hearing defects in humans and in mice. In contrast to mammals the embryonic and larval zebrafish routinely studied are transparent and develop externally, therefore hair cells in zebrafish can be studied in vivo.
Dr. Kindt received a B.S. degree in Molecular Biology and Biochemistry from the University Wisconsin-Eau Claire, and a Ph.D. in Biomedical Sciences from the University of California-San Diego, where she studied the function and development of mechanosensory circuits in Caenorhabditis elegans in the laboratory of William Schafer. During a postdoctoral fellowship with Teresa Nicolson at the Vollum institute she used a combination of scanning electron microscopy in vivo calcium imaging to investigate the role of the primary cilium in developing hair cells (Figure 1). Dr. Kindt joined the NIDCD as an investigator in 2013. Her laboratory uses molecular and microscopy-based methods to examine sensory cell function and development in the zebrafish model system.
- Kindt KS, Akturk A, Jarysta A, Day M, Beirl A, Flonard M, Tarchini B. EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia. Nat Commun. 2021;12(1):2861.
- Zhang Q, Li S, Wong HC, He XJ, Beirl A, Petralia RS, Wang YX, Kindt KS. Synaptically silent sensory hair cells in zebrafish are recruited after damage. Nat Commun. 2018;9(1):1388.
- Jiang T, Kindt K, Wu DK. Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells. Elife. 2017;6.
- Sheets L, He XJ, Olt J, Schreck M, Petralia RS, Wang YX, Zhang Q, Beirl A, Nicolson T, Marcotti W, Trapani JG, Kindt KS. Enlargement of Ribbons in Zebrafish Hair Cells Increases Calcium Currents But Disrupts Afferent Spontaneous Activity and Timing of Stimulus Onset. J Neurosci. 2017;37(26):6299-6313.
- Ji YR, Warrier S, Jiang T, Wu DK, Kindt KS. Directional selectivity of afferent neurons in zebrafish neuromasts is regulated by Emx2 in presynaptic hair cells. Elife. 2018;7.
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This page was last updated on Friday, August 27, 2021