Joshua Farber, M.D.
Inflammation Biology Section
Building 10, Room 11N112
10 Center Drive
Bethesda, MD 20892
Chemokines and their receptors are proteins important for leukocyte trafficking, are critical in immune responses and inflammation, and are emerging therapeutic targets in HIV and a variety of immune-mediated diseases.
Recently, members of the Inflammation Biology Section have been using the chemokine system to investigate the activities of human T-cell subsets and the differentiation of memory T cells, including the newly recognized Th17 cells; to understand cellular and molecular mechanisms in medically relevant models of inflammatory tissue injury, including models of Th17-cell mediated disease; and to develop new tools for clinical imaging in cancer and inflammation.
Dr. Farber obtained his M.D. from The Johns Hopkins University, where he did additional clinical training in internal medicine and infectious diseases. Dr. Farber's postdoctoral training in bench research was both at the National Institutes of Health and at Johns Hopkins. Dr. Farber joined the NIAID Laboratory of Clinical Investigation in 1993, became a senior investigator in 2000, and moved to the Laboratory of Molecular Immunology at its inception in 2004.
Singh TP, Zhang HH, Borek I, Wolf P, Hedrick MN, Singh SP, Kelsall BL, Clausen BE, Farber JM. Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation. Nat Commun. 2016;7:13581.
Zhang HH, Song K, Rabin RL, Hill BJ, Perfetto SP, Roederer M, Douek DC, Siegel RM, Farber JM. CCR2 identifies a stable population of human effector memory CD4+ T cells equipped for rapid recall response. J Immunol. 2010;185(11):6646-63.
Singh SP, Zhang HH, Tsang H, Gardina PJ, Myers TG, Nagarajan V, Lee CH, Farber JM. PLZF regulates CCR6 and is critical for the acquisition and maintenance of the Th17 phenotype in human cells. J Immunol. 2015;194(9):4350-61.
Singh SP, Zhang HH, Foley JF, Hedrick MN, Farber JM. Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J Immunol. 2008;180(1):214-21.
Hedrick MN, Lonsdorf AS, Shirakawa AK, Richard Lee CC, Liao F, Singh SP, Zhang HH, Grinberg A, Love PE, Hwang ST, Farber JM. CCR6 is required for IL-23-induced psoriasis-like inflammation in mice. J Clin Invest. 2009;119(8):2317-29.
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This page was last updated on February 15th, 2017