Joseph Rodriguez, Ph.D.
Epigenetics and Stem Cell Biology Laboratory / Single Cell Dynamics Group
D425 Rall Building
111 T W Alexander Dr
Research Triangle Park, NC 27709
We study how the environment influences expression variability at the single cell level and subsequently how this variability influences cell fate decisions.
Our understanding of gene regulation is mostly based on studies which assay whole tissues and bulk cell lysates. My group is interested in understanding why genetically identical cells respond heterogenous to environmental stimuli. Recent research suggests that in diseases such as cancer or the process of aging, expression variability increases in tissue. Determining the factors and mechanisms that regulate this variability will help us understand the differences between normal and diseased states.
Ren G, Jin W, Cui K, Rodrigez J, Hu G, Zhang Z, Larson DR, Zhao K. CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression. Mol Cell. 2017;67(6):1049-1058.e6.
Related Scientific Focus Areas
Biomedical Engineering and Biophysics
This page was last updated on January 17th, 2020