Joseph Rodriguez, Ph.D.
Epigenetics and Stem Cell Biology Laboratory / Single Cell Dynamics Group
D425 Rall Building
111 T W Alexander Dr
Research Triangle Park, NC 27709
We study how the environment influences expression heterogeneity in real time and how those impacts affect tissue composition. We also want to determine how different compounds affect heterogeneity and how they lead to disease.
The work is important because the current understanding of gene regulation is based on studies using bulk cells and ground up tissues. My group has found that individual cells, even of the same cell type, respond differently to upstream signals, which include the environment. Our recent research suggests that in diseases, such as cancer or the process of aging, cells express a lot of heterogeneity. Understanding the mechanisms of that heterogeneity at the single cell level is vital for figuring out what happens in normal and diseased states.
Ren G, Jin W, Cui K, Rodrigez J, Hu G, Zhang Z, Larson DR, Zhao K. CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression. Mol Cell. 2017;67(6):1049-1058.e6.
Related Scientific Focus Areas
Biomedical Engineering and Biophysics
This page was last updated on January 22nd, 2019