John Cidlowski, Ph.D.

Senior Investigator

Signal Transduction Laboratory / Molecular Endocrinology Group

NIEHS

F348 Rall Building
111 T W Alexander Dr
Research Triangle Park, NC 27709

984-287-3545

cidlows1@niehs.nih.gov

Research Topics

The Molecular Endocrinology Group is comprised of 12 researchers with approximately half of the scientist focusing their efforts on glucocorticoids receptor signaling and half on apoptosis and the immune system.

The goal of our research is to elucidate how cells and tissues respond to both environmental and physiological stressors. Insights into stress signaling pathways can aid in the understanding of complex human disease processes and improve disease therapy. We focus our research efforts on the actions of glucocorticoids, a primary stress response hormone released from the adrenal gland following the activation of the stress responses.

A second focus of our research group has been to understand actions of glucocorticoids on apoptosis in the immune system and specifically their role in T-lymphoid cell apoptosis. Apoptosis, or programmed cell death, has now been associated with more than 50 human diseases including cancer, AIDS and Alzheimer's disease. Apoptosis has a strong environmental component which reflects its activation by a variety of environmental contaminants including herbicides, arsenic, TCDD, PAHs, cadmium, asbestos and diesel combustion particles. We seek to understand the molecular mechanisms that cells employ to activate and/or inhibit apoptosis with specific emphasis on defining how the function of ion channels and volume regulatory processes impinge on cell life/death decisions. In addition, recent discoveries have shown a remarkable stimulatory action of glucocorticoids on components of innate immunity and unprecedented synergy with proinflammatory signaling molecules. These are both unique areas of research that we defined.

Biography

John A. Cidlowski, Ph.D., heads the Molecular Endocrinology Group within the Laboratory of Signal Transduction (LST), and is Chief of the LST. He received his Ph.D. in 1975 from Medical College of Georgia in Endocrinology. He has published over 300 peer-reviewed articles in leading biomedical journals, as well as several book chapters. He served as Professor of Physiology and Biochemistry at University of North Carolina at Chapel Hill before joining the NIEHS in 1995.

Selected Publications

  1. Busada JT, Ramamoorthy S, Cain DW, Xu X, Cook DN, Cidlowski JA. Endogenous glucocorticoids prevent gastric metaplasia by suppressing spontaneous inflammation. J Clin Invest. 2019;129(3):1345-1358.

  2. Cruz-Topete D, Oakley RH, Carroll NG, He B, Myers PH, Xu X, Watts MN, Trosclair K, Glasscock E, Dominic P, Cidlowski JA. Deletion of the Cardiomyocyte Glucocorticoid Receptor Leads to Sexually Dimorphic Changes in Cardiac Gene Expression and Progression to Heart Failure. J Am Heart Assoc. 2019;8(15):e011012.

  3. Oakley RH, Cruz-Topete D, He B, Foley JF, Myers PH, Xu X, Gomez-Sanchez CE, Chambon P, Willis MS, Cidlowski JA. Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice. Sci Signal. 2019;12(577).

  4. Petrillo MG, Oakley RH, Cidlowski JA. β-Arrestin-1 inhibits glucocorticoid receptor turnover and alters glucocorticoid signaling. J Biol Chem. 2019;294(29):11225-11239.

  5. Quinn MA, McCalla A, He B, Xu X, Cidlowski JA. Silencing of maternal hepatic glucocorticoid receptor is essential for normal fetal development in mice. Commun Biol. 2019;2:104.


This page was last updated on August 26th, 2020