Dr. Jill Koshiol studies hepatobiliary cancers, which are linked to both infections and inflammation. Biliary tract cancers are rare in much of the world, but there are hotspots where these cancers constitute a major public health burden. Because these cancers are rare in the developed world, their etiology is poorly understood, even with respect to classic cancer risk factors. Biliary tract cancers have a multifactorial etiology, and inflammation is likely central in the carcinogenesis process. Dr. Koshiol’s work is identifying previously unknown risk factors, such as aflatoxin. Identification of such determinants, as well as biomarkers, may lead to new opportunities for cancer prevention and early detection that can be translated into public health impact, particularly in high-risk areas.
Chile is one such high-risk area. Gallbladder cancer (GBC) is a leading cause of cancer death in Chilean women. To investigate the epidemiologic and molecular predictors of gallbladder dysplasia and cancer, Dr. Koshiol initiated the Chile Biliary Longitudinal Study (Chile BiLS). The very high rates of GBC and gallstones in Chile provide a unique opportunity to test several emerging hypotheses that are difficult to examine in other populations.
Dr. Koshiol is also the principal investigator for the Shanghai Biliary Tract Cancer Study and leads the Biliary Tract Cancer Pooling Project. In addition, she collaborates on the REVEAL-HBV and -HCV studies of individuals with chronic hepatitis B and C infection. Using these studies and others, she plans to elucidate hepatobiliary cancer etiology and aid cancer prevention through the identification of cancer-related molecular pathways and targets.
Dr. Koshiol received her Ph.D. in epidemiology from the University of North Carolina at Chapel Hill School of Public Health in 2005. Subsequently, she joined the Genetic Epidemiology Branch of the Division of Cancer Epidemiology and Genetics as a Cancer Prevention Fellow. Dr. Koshiol joined the Infections and Immunoepidemiology Branch as a research fellow in 2008, became an Earl Stadtman Tenure-Track Investigator in 2010, and was awarded NIH scientific tenure and promoted to senior investigator in 2020. Dr. Koshiol received the Hubert H. Humphrey Award for Service to America in 2022.
- Roa JC, García P, Kapoor VK, Maithel SK, Javle M, Koshiol J. Gallbladder cancer. Nat Rev Dis Primers. 2022;8(1):69.
- Jackson SS, Pfeiffer RM, Gabbi C, Anderson L, Gadalla SM, Koshiol J. Menopausal hormone therapy and risk of biliary tract cancers. Hepatology. 2022;75(2):309-321.
- Jackson SS, Pfeiffer RM, Liu Z, Anderson LA, Tsai HT, Gadalla SM, Koshiol J. Association Between Aspirin Use and Biliary Tract Cancer Survival. JAMA Oncol. 2019;5(12):1802-1804.
- McGee EE, Jackson SS, Petrick JL, Van Dyke AL, Adami HO, Albanes D, Andreotti G, Beane-Freeman LE, Berrington de Gonzalez A, Buring JE, Chan AT, Chen Y, Fraser GE, Freedman ND, Gao YT, Gapstur SM, Gaziano JM, Giles GG, Grant EJ, Grodstein F, Hartge P, Jenab M, Kitahara CM, Knutsen SF, Koh WP, Larsson SC, Lee IM, Liao LM, Luo J, Milne RL, Monroe KR, Neuhouser ML, O'Brien KM, Peters U, Poynter JN, Purdue MP, Robien K, Sandler DP, Sawada N, Schairer C, Sesso HD, Simon TG, Sinha R, Stolzenberg-Solomon R, Tsugane S, Wang R, Weiderpass E, Weinstein SJ, White E, Wolk A, Yuan JM, Zeleniuch-Jacquotte A, Zhang X, Zhu B, McGlynn KA, Campbell PT, Koshiol J. Smoking, Alcohol, and Biliary Tract Cancer Risk: A Pooling Project of 26 Prospective Studies. J Natl Cancer Inst. 2019;111(12):1263-1278.
- Nogueira L, Foerster C, Groopman J, Egner P, Koshiol J, Ferreccio C, Gallbladder Cancer Chile Working Group. Association of aflatoxin with gallbladder cancer in Chile. JAMA. 2015;313(20):2075-7.
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This page was last updated on Tuesday, May 9, 2023