Jenny E. Hinshaw, Ph.D.

Senior Investigator

Structural Cell Biology Section, Laboratory of Cell & Molecular Biology

NIDDK

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Building NIHBC 08, Room 1A03
8 Center Dr
Bethesda, MD 20892

+1 301 594 0842

jenny.hinshaw@nih.gov

Research Topics

Our goal is to understand the dynamic structural properties of dynamins and correlate them with their diverse cellular functions.

Biography

  • Ph.D., Brown University, 1989
  • B.A., Wellesley College, 1982

Selected Publications

  1. Jimah JR, Kundu N, Stanton AE, Sochacki KA, Canagarajah B, Chan L, Strub MP, Wang H, Taraska JW, Hinshaw JE. Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission. Dev Cell. 2024;59(14):1783-1793.e5.
  2. Nyenhuis SB, Wu X, Strub MP, Yim YI, Stanton AE, Baena V, Syed ZA, Canagarajah B, Hammer JA, Hinshaw JE. OPA1 helical structures give perspective to mitochondrial dysfunction. Nature. 2023;620(7976):1109-1116.
  3. Doyle MT, Jimah JR, Dowdy T, Ohlemacher SI, Larion M, Hinshaw JE, Bernstein HD. Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding. Cell. 2022;185(7):1143-1156.e13.
  4. Zhang R, Lee DM, Jimah JR, Gerassimov N, Yang C, Kim S, Luvsanjav D, Winkelman J, Mettlen M, Abrams ME, Kalia R, Keene P, Pandey P, Ravaux B, Kim JH, Ditlev JA, Zhang G, Rosen MK, Frost A, Alto NM, Gardel M, Schmid SL, Svitkina TM, Hinshaw JE, Chen EH. Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein. Nat Cell Biol. 2020;22(6):674-688.
  5. Kong L, Sochacki KA, Wang H, Fang S, Canagarajah B, Kehr AD, Rice WJ, Strub MP, Taraska JW, Hinshaw JE. Cryo-EM of the dynamin polymer assembled on lipid membrane. Nature. 2018;560(7717):258-262.

Related Scientific Focus Areas

This page was last updated on Thursday, November 7, 2024