Jenny E. Hinshaw, Ph.D.

Senior Investigator

Structural Cell Biology Section, Laboratory of Cell and Molecular Biology

NIDDK

Building 8A, Room 1A03
8 Center Dr
Bethesda, MD 20814

+1 301 594 0842

jenny.hinshaw@nih.gov

Research Topics

Our goal is to understand the dynamic structural properties of dynamins and correlate them with their diverse cellular functions.

Biography

  • Ph.D., Brown University, 1989
  • B.A., Wellesley College, 1982

Selected Publications

  1. Kong L, Sochacki KA, Wang H, Fang S, Canagarajah B, Kehr AD, Rice WJ, Strub MP, Taraska JW, Hinshaw JE. Cryo-EM of the dynamin polymer assembled on lipid membrane. Nature. 2018;560(7717):258-262.

  2. Mattila JP, Shnyrova AV, Sundborger AC, Hortelano ER, Fuhrmans M, Neumann S, Müller M, Hinshaw JE, Schmid SL, Frolov VA. A hemi-fission intermediate links two mechanistically distinct stages of membrane fission. Nature. 2015;524(7563):109-113.

  3. Sundborger AC, Fang S, Heymann JA, Ray P, Chappie JS, Hinshaw JE. A dynamin mutant defines a superconstricted prefission state. Cell Rep. 2014;8(3):734-42.

  4. Chappie JS, Mears JA, Fang S, Leonard M, Schmid SL, Milligan RA, Hinshaw JE, Dyda F. A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke. Cell. 2011;147(1):209-22.

  5. Mears JA, Lackner LL, Fang S, Ingerman E, Nunnari J, Hinshaw JE. Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission. Nat Struct Mol Biol. 2011;18(1):20-6.


This page was last updated on August 1st, 2019