Jenny E. Hinshaw, Ph.D.

Senior Investigator

Structural Cell Biology Section, Laboratory of Cell and Molecular Biology

NIDDK

Building 8, Room 1A03
8 Center Dr
Bethesda, MD 20814

+1 301 594 0842

jenny.hinshaw@nih.gov

Research Topics

Our goal is to understand the dynamic structural properties of dynamins and correlate them with their diverse cellular functions.

Biography

  • Ph.D., Brown University, 1989
  • B.A., Wellesley College, 1982

Selected Publications

  1. Zhang R, Lee DM, Jimah JR, Gerassimov N, Yang C, Kim S, Luvsanjav D, Winkelman J, Mettlen M, Abrams ME, Kalia R, Keene P, Pandey P, Ravaux B, Kim JH, Ditlev JA, Zhang G, Rosen MK, Frost A, Alto NM, Gardel M, Schmid SL, Svitkina TM, Hinshaw JE, Chen EH. Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein. Nat Cell Biol. 2020;22(6):674-688.

  2. Kong L, Sochacki KA, Wang H, Fang S, Canagarajah B, Kehr AD, Rice WJ, Strub MP, Taraska JW, Hinshaw JE. Cryo-EM of the dynamin polymer assembled on lipid membrane. Nature. 2018;560(7717):258-262.

  3. Mattila JP, Shnyrova AV, Sundborger AC, Hortelano ER, Fuhrmans M, Neumann S, Müller M, Hinshaw JE, Schmid SL, Frolov VA. A hemi-fission intermediate links two mechanistically distinct stages of membrane fission. Nature. 2015;524(7563):109-113.

  4. Sundborger AC, Fang S, Heymann JA, Ray P, Chappie JS, Hinshaw JE. A dynamin mutant defines a superconstricted prefission state. Cell Rep. 2014;8(3):734-42.

  5. Chappie JS, Mears JA, Fang S, Leonard M, Schmid SL, Milligan RA, Hinshaw JE, Dyda F. A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke. Cell. 2011;147(1):209-22.


This page was last updated on October 15th, 2020