Jennifer Clare Jones, M.D., Ph.D.

Stadtman Investigator

Laboratory of Pathology

NCI/CCR

Building 10-CRC, Room B2-3500
Bethesda, MD 20892-5062

301-496-5457

jennifer.jones2@nih.gov

Research Topics

The Jones Lab has two primary research goals:

1) Developing optimal strategies for combining immune-based therapies with radiation to produce optimal anti-tumor immune responses. 

2) Developing new ways to investigate (characterize and categorize) extracellular vesicles, as biological agents, biomarkers, and therapeutic targets.  Tumor cells, immune cells, and irradiated tissues release large quantities of biologically active (and distinct) nanoscale extracellular vesicles (e.g., exosomes and microparticles). The Jones Lab combines leading edge technologies and new methods together in a cohesive translational pipeline to investigate extracellular vesicles. This research involves developing improved methods in three broad categories: 1) how samples are collected and processed, 2) establishing high-throughput and precise methods to characterize extracellular vesicles, and 3) utilizing extracellular vesicle data to better understand tumor- and immune-biology and to establish a foundation for next-generation EV-based personalized cancer treatment and monitoring.

My current research focuses on developing immune-based therapies that synergize with radiation to produce optimal anti-tumor immune responses.

Tumor cells, immune cells, and irradiated tissues release large quantities of biologically active (and distinct) nanoscale extracellular vesicles (e.g., exosomes and microparticles). Our laboratory is developing improved methods to characterize, sort, and perform functional studies of nanoparticles, and has established a flow cytometry core facility, with instrumentation for preparation, analysis, counting, and cytometric study of extracellular vesicles.

Biography

Dr. Jones received her M.D. and Ph.D. from Stanford University. She is a board-certified radiation oncologist specialized training in radiosurgery, with graduate and postdoctoral training in both cancer biology and general immunology.

Awards:

  • Pamela Anne Cafritz Renal Cell Carcinoma Award, 2018
  • Prostate Cancer Foundation Young Investigator Award, 2018 - present
  • Federal Technology Transfer Awards, 2014 - 2018
  • ASCO/AACR Methods in Clinical Cancer Trials Workshop Fellowship, 2011
  • Stanford University Dean’s Postdoctoral Fellowship, 2011
  • American Association for Women Radiologists (AAWR): Member-In-Training Award, 2008
  • American Association of Immunologists Trainee Achievement Award, 2004
  • Western Association for Medical Research Annual Meeting: Edwin E. Osgood Award, 1998
  • American Academy of Allergy, Asthma, and Immunology (AAAAI): Travel Award, 1997
  • Cum Laude, Princeton University, 1994

Selected Publications

  1. Parker JJ, Jones JC, Strober S, Knox SJ. Characterization of direct radiation-induced immune function and molecular signaling changes in an antigen presenting cell line. Clin Immunol. 2013;148(1):44-55.

  2. Jones JC, Freeman GJ. Costimulatory genes: hotspots of conflict between host defense and autoimmunity. Immunity. 2013;38(6):1083-5.

  3. Fasola CE, Jones JC, Huang DD, Le QT, Hoppe RT, Donaldson SS. Low-dose radiation therapy (2 Gy × 2) in the treatment of orbital lymphoma. Int J Radiat Oncol Biol Phys. 2013;86(5):930-5.

  4. Hiniker SM, Chen DS, Reddy S, Chang DT, Jones JC, Mollick JA, Swetter SM, Knox SJ. A systemic complete response of metastatic melanoma to local radiation and immunotherapy. Transl Oncol. 2012;5(6):404-7.

  5. Yao Z, Jones J, Kohrt H, Strober S. Selective resistance of CD44hi T cells to p53-dependent cell death results in persistence of immunologic memory after total body irradiation. J Immunol. 2011;187(8):4100-8.


This page was last updated on September 13th, 2019