Jennifer Clare Jones, M.D., Ph.D.
Assistant Clinical Investigator
Building 41, Room D702B
Bethesda, MD 20892-5062
My current research focuses on developing immune-based therapies that synergize with radiation to produce optimal anti-tumor immune responses.
Tumor cells, immune cells, and irradiated tissues release large quantities of biologically active (and distinct) nanoscale extracellular vesicles (e.g., exosomes and microparticles). Our laboratory is developing improved methods to characterize, sort, and perform functional studies of nanoparticles, and has established a flow cytometry core facility, with instrumentation for preparation, analysis, counting, and cytometric study of extracellular vesicles.
Parker JJ, Jones JC, Strober S, Knox SJ. Characterization of direct radiation-induced immune function and molecular signaling changes in an antigen presenting cell line. Clin Immunol. 2013;148(1):44-55.
Jones JC, Freeman GJ. Costimulatory genes: hotspots of conflict between host defense and autoimmunity. Immunity. 2013;38(6):1083-5.
Fasola CE, Jones JC, Huang DD, Le QT, Hoppe RT, Donaldson SS. Low-dose radiation therapy (2 Gy × 2) in the treatment of orbital lymphoma. Int J Radiat Oncol Biol Phys. 2013;86(5):930-5.
Hiniker SM, Chen DS, Reddy S, Chang DT, Jones JC, Mollick JA, Swetter SM, Knox SJ. A systemic complete response of metastatic melanoma to local radiation and immunotherapy. Transl Oncol. 2012;5(6):404-7.
Yao Z, Jones J, Kohrt H, Strober S. Selective resistance of CD44hi T cells to p53-dependent cell death results in persistence of immunologic memory after total body irradiation. J Immunol. 2011;187(8):4100-8.
Related Scientific Focus Areas
Biomedical Engineering and Biophysics
Genetics and Genomics
This page was last updated on June 15th, 2017