Jeffrey S. Diamond, Ph.D.
Senior Investigator
Synaptic Physiology Section
NINDS
Scientific Director
NINDS
Research Topics
Our laboratory seeks to understand how neural circuits receive, compute, encode and transmit information. More specifically, we’d like to learn what biophysical and morphological features equip synapses, neurons and networks to perform these tasks. The retina is a wonderful model system for the study of neuronal information processing: We can deliver precisely defined physiological stimuli and record responses from many different cell types at various points within the network; in addition, retinal circuitry is particularly well understood, enabling us to interpret more directly the impact of synaptic and cellular mechanisms on circuit function. We have exploited these advantages to examine how synapses and neurons within retinal circuits perform specific visual computations.
Biography
Dr. Diamond received his B.S. from Duke University in 1989 and his Ph.D. from the University of California, San Francisco in 1994, where he studied excitatory synaptic transmission in the retina with David Copenhagen. During a postdoctoral fellowship with Craig Jahr at the Vollum Institute, he investigated the effects of glutamate transporters on excitatory synaptic transmission in the hippocampus. Dr. Diamond joined NINDS as an investigator in 1999, was awarded the Presidential Early Career Award in Science and Engineering in 2000 and was promoted to Senior Investigator in 2007. His laboratory studies how synapses, neurons and small circuits perform computational tasks required for visual information processing in the mammalian retina.
Selected Publications
- Nath A, Grimes WN, Diamond JS. Layers of inhibitory networks shape receptive field properties of AII amacrine cells. Cell Rep. 2023;42(11):113390.
- Armbruster M, Dulla CG, Diamond JS. Effects of fluorescent glutamate indicators on neurotransmitter diffusion and uptake. Elife. 2020;9.
- Graydon CW, Lieberman EE, Rho N, Briggman KL, Singer JH, Diamond JS. Synaptic Transfer between Rod and Cone Pathways Mediated by AII Amacrine Cells in the Mouse Retina. Curr Biol. 2018;28(17):2739-2751.e3.
- Ding H, Smith RG, Poleg-Polsky A, Diamond JS, Briggman KL. Species-specific wiring for direction selectivity in the mammalian retina. Nature. 2016;535(7610):105-10.
- Poleg-Polsky A, Diamond JS. NMDA Receptors Multiplicatively Scale Visual Signals and Enhance Directional Motion Discrimination in Retinal Ganglion Cells. Neuron. 2016;89(6):1277-1290.
Related Scientific Focus Areas
Biomedical Engineering and Biophysics
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This page was last updated on Sunday, September 1, 2024