Jeffrey Baron, M.D.
Section on Growth and Development
We investigate the cellular and molecular mechanisms governing childhood growth and development. We particularly focus on growth at the growth plate, which drives bone elongation and therefore determines height. One goal of this work is to gain insight into the many human genetic disorders that cause childhood growth failure and overgrowth. A second goal is to develop new treatments for children with severe growth disorders.
Dr. Jeffrey Baron is a senior investigator and head of the Section on Growth and Development in NICHD. He received his M.D. degree from the University of Texas Southwestern Medical School. He completed a residency in pediatrics at Yale-New Haven Hospital and a fellowship in pediatric endocrinology in the Developmental Endocrinology Branch of NICHD.
The Section on Growth and Development, headed by Dr. Baron, investigates the cellular and molecular mechanisms governing childhood growth and development. In addition to his research role, Dr. Baron serves as an attending physician for the pediatric endocrinology clinic and consultative service and teaches clinical fellows in the NICHD pediatric endocrinology training program.
Nilsson O, Weise M, Landman EB, Meyers JL, Barnes KM, Baron J. Evidence that estrogen hastens epiphyseal fusion and cessation of longitudinal bone growth by irreversibly depleting the number of resting zone progenitor cells in female rabbits. Endocrinology. 2014;155(8):2892-9.
Lui JC, Baron J. Evidence that Igf2 down-regulation in postnatal tissues and up-regulation in malignancies is driven by transcription factor E2f3. Proc Natl Acad Sci U S A. 2013;110(15):6181-6.
Lui JC, Garrison P, Nguyen Q, Ad M, Keembiyehetty C, Chen W, Jee YH, Landman E, Nilsson O, Barnes KM, Baron J. EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy. Nat Commun. 2016;7:13685.
Lui JC, Forcinito P, Chang M, Chen W, Barnes KM, Baron J. Coordinated postnatal down-regulation of multiple growth-promoting genes: evidence for a genetic program limiting organ growth. FASEB J. 2010;24(8):3083-92.
Lui JC, Nilsson O, Chan Y, Palmer CD, Andrade AC, Hirschhorn JN, Baron J. Synthesizing genome-wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate height. Hum Mol Genet. 2012;21(23):5193-201.
Related Scientific Focus Areas
Genetics and Genomics
This page was last updated on October 4th, 2018