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Jeffrey Baron, M.D.

Senior Investigator

Section on Growth and Development

NICHD

Building 10, Room 1-3330
10 Center Drive
Bethesda, MD 20892

301-496-6312

jb233v@nih.gov

Research Topics

Regulation of Childhood Growth

We investigate the cellular and molecular mechanisms governing childhood growth and development. We are especially interested in mechanisms that allow rapid cell proliferation and hence rapid body growth in young mammals and that subsequently suppress proliferation, thus setting a fundamental limit on the adult body size of the species. One goal of this work is to gain insight into the many human genetic disorders that cause childhood growth failure or overgrowth. In addition, further investigation of the identified growth-limiting mechanisms may lead to broader medical applications, because disruption of these mechanisms may contribute to oncogenesis, and conversely transient therapeutic suspension of growth-limiting mechanisms in adult cells might be used to achieve tissue regeneration.

Biography

Dr. Jeffrey Baron is a senior investigator and head of the Section on Growth and Development in NICHD. He received his M.D. degree from the University of Texas Southwestern Medical School. He completed a residency in pediatrics at Yale-New Haven Hospital and a fellowship in pediatric endocrinology in the Developmental Endocrinology Branch of NICHD. The Section on Growth and Development, headed by Dr. Baron, investigates the cellular and molecular mechanisms governing childhood growth and development. Recently this research group has focused on the mechanisms that allow rapid proliferation and hence rapid body growth in young mammals and subsequently suppress proliferation, thus setting a fundamental limit on the adult body size of the species. One goal of this work is to gain insight into the many human genetic disorders that cause childhood growth failure and overgrowth. In addition, further investigation of the identified growth-limiting mechanisms may lead to broader medical applications, because disruption of these mechanisms may contribute to oncogenesis, and conversely transient therapeutic suspension of growth-limiting mechanisms in adult cells might be used to achieve tissue regeneration. In addition to his research role, Dr. Baron serves as an attending physician for the pediatric endocrinology clinic and consultative service and teaches clinical fellows in the NICHD pediatric endocrinology training program.

Selected Publications

  1. Cheung CS, Zhu Z, Lui JC, Dimitrov D, Baron J. Human monoclonal antibody fragments targeting matrilin-3 in growth plate cartilage. Pharm Res. 2015;32(7):2439-49.
  2. Lui JC, Forcinito P, Chang M, Chen W, Barnes KM, Baron J. Coordinated postnatal down-regulation of multiple growth-promoting genes: evidence for a genetic program limiting organ growth. FASEB J. 2010;24(8):3083-92.
  3. Lui JC, Nilsson O, Chan Y, Palmer CD, Andrade AC, Hirschhorn JN, Baron J. Synthesizing genome-wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate height. Hum Mol Genet. 2012;21(23):5193-201.
This page was last updated on October 18th, 2011