Jozef (Jeff) H. Duyn, Ph.D.

Senior Investigator

Advanced MRI Section, Laboratory of Functional and Molecular Imaging

NINDS

View Site

Building 10, Room B1D724
10 Center Drive
Bethesda, MD 20814

301-594-7305

jeff.duyn@nih.gov

Research Topics

In addition to providing structural information, MRI has the potential to non-invasively map physiologic parameters and function. Our research focuses on optimally exploiting this potential by investigating the mechanisms behind MRI contrast, exploring avenues to manipulate the contrast, and optimizing MRI data acquisition and analysis to achieve optimum sensitivity, resolution, reliability, and accuracy. Specific aims are the development of MRI techniques for the measurements of structural anatomy, tissue metabolism, tissue perfusion, and the spatial distribution of brain activity. Recent research has focused on the use of advanced MRI methods to map brain iron and myelin changes with neurodegenerative disease, and combining MRI with (electro) physiology to reveal the dependence of the brain’s physiology and functional connectivity on arousal state.

Biography

Dr. Duyn received his M.Sc. and Ph.D. degrees in physics at the University of Delft, Holland where he was involved with the development of X-ray diffraction techniques, as well as the early development of magnetic resonance imaging (MRI). During his postdoctoral assignments at the University of California, San Francisco, and at NIH, his research focused on the study of human brain physiology, as measured by spectroscopic and functional MRI techniques. Dr. Duyn moved to NINDS in 2000.

Selected Publications

  1. Özbay PS, Chang C, Picchioni D, Mandelkow H, Chappel-Farley MG, van Gelderen P, de Zwart JA, Duyn J. Sympathetic activity contributes to the fMRI signal. Commun Biol. 2019;2:421.
  2. Picchioni D, Özbay PS, Mandelkow H, de Zwart JA, Wang Y, van Gelderen P, Duyn JH. Autonomic arousals contribute to brain fluid pulsations during sleep. Neuroimage. 2022;249:118888.
  3. Yang Y, Leopold DA, Duyn JH, Sipe GO, Liu X. Sensory Encoding Alternates With Hippocampal Ripples across Cycles of Forebrain Spiking Cascades. Adv Sci (Weinh). 2025;12(16):e2406224.
  4. van Gelderen P, Wang Y, de Zwart JA, Duyn JH. Dependence of brain-tissue R(2) on MRI field strength. Magn Reson Med. 2025;93(5):2140-2152.
  5. Bolt T, Wang S, Nomi JS, Setton R, Gold BP, deB Frederick B, Yeo BTT, Chen JJ, Picchioni D, Duyn JH, Spreng RN, Keilholz SD, Uddin LQ, Chang C. Autonomic physiological coupling of the global fMRI signal. Nat Neurosci. 2025;28(6):1327-1335.

Related Scientific Focus Areas

This page was last updated on Tuesday, September 23, 2025