Jason Elinoff, M.D.


Critical Care Medicine Department

NIH Clinical Center

Building 10, Room 4D03
10 Center Drive
Bethesda, MD 20892



Research Topics

His research interests include endothelial biology and the role of the endothelium in both acute (septic shock) and chronic (pulmonary arterial hypertension) forms of inflammation.


Dr. Jason Elinoff is currently an Assistant Clinical Investigator in the Clinical Center's Critical Care Medicine Department and serves as the co-director of the department's Critical Care Ultrasound Training Program.

Dr. Elinoff earned his undergraduate degree in Chemistry from Princeton University and his degree in Medicine from the University of Chicago Pritzker School of Medicine. He went on to complete internship and residency training in Internal Medicine at the Massachusetts General Hospital. Following his fellowship training in Critical Care Medicine at the NIH and Pulmonary and Critical Care Medicine at Johns Hopkins University, Dr. Elinoff was appointed to Staff Clinician in the Critical Care Medicine Department at the NIH in 2011.

Selected Publications

  1. Elinoff JM, Chen LY, Dougherty EJ, Awad KS, Wang S, Biancotto A, Siddiqui AH, Weir NA, Cai R, Sun J, Preston IR, Solomon MA, Danner RL. Spironolactone-induced degradation of the TFIIH core complex XPB subunit suppresses NF-κB and AP-1 signalling. Cardiovasc Res. 2018;114(1):65-76.

  2. Awad KS, Elinoff JM, Wang S, Gairhe S, Ferreyra GA, Cai R, Sun J, Solomon MA, Danner RL. Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2016;310(2):L187-201.

  3. Dougherty EJ, Elinoff JM, Ferreyra GA, Hou A, Cai R, Sun J, Blaine KP, Wang S, Danner RL. Mineralocorticoid Receptor (MR) trans-Activation of Inflammatory AP-1 Signaling: DEPENDENCE ON DNA SEQUENCE, MR CONFORMATION, AND AP-1 FAMILY MEMBER EXPRESSION. J Biol Chem. 2016;291(45):23628-23644.

  4. Wang S, Awad KS, Elinoff JM, Dougherty EJ, Ferreyra GA, Wang JY, Cai R, Sun J, Ptasinska A, Danner RL. G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ): AN INTEGRATED TWO-RECEPTOR SIGNALING PATHWAY. J Biol Chem. 2015;290(32):19544-57.

  5. Elinoff JM, Rame JE, Forfia PR, Hall MK, Sun J, Gharib AM, Abd-Elmoniem K, Graninger G, Harper B, Danner RL, Solomon MA. A pilot study of the effect of spironolactone therapy on exercise capacity and endothelial dysfunction in pulmonary arterial hypertension: study protocol for a randomized controlled trial. Trials. 2013;14:91.

This page was last updated on February 6th, 2020