Jacqueline Mays, DDS, MHSc, PhD
Lasker Clinical Research Scholar
Oral Immunobiology Unit
Building 30 Room 301
30 Convent Dr MSC 4340
Bethesda MD 20892-4326
Dr. Mays leads a clinical and translational research unit that investigates oral mucosal immunity, by using chronic graft-versus-host disease (cGVHD) as a model for study. cGVHD is an autoimmune-like condition that manifests after allogeneic hematopoietic stem cell transplantation. Symptoms include salivary gland dysfunction, oral lesions, and limited mouth-opening from perioral fibrosis. The underlying immunologic events that target the oral cavity and the mechanisms that drive the pathogenic process, particularly in salivary glands, are not well-understood. Consequently, targeted therapeutics are limited. Dr. Mays’ research program aims to elucidate the underlying immune process of cGVHD in the oral cavity (with a focus on the salivary glands), and then translate that knowledge into improved monitoring and therapeutics for people with cGVHD.
Dr. Jacqueline W. Mays received a BS in biology and chemistry from Valparaiso University, Ind., and a PhD in oral biology and a DDS from the College of Dentistry, The Ohio State University. Dr. Mays was awarded a Master of Health Sciences in Clinical Research from the College of Medicine at Duke University. Dr. Mays performed post-doctoral work at the National Institute of Allergy and Infectious Diseases (NIAID) on influenza viral protein expression and the anti-viral mucosal immune response, and subsequently completed a Clinical Research Fellowship at NIDCR focused on chronic Graft-versus-Host Disease (cGVHD) in the oral cavity. Dr. May was appointed chief of the Oral Immunobiology Unit at NIDCR in 2015. Dr. Mays’ laboratory is focused on translational investigation of cGVHD pathobiology and the development of new therapies for the oral cavity.
Mays JW, Fassil H, Edwards DA, Pavletic SZ, Bassim CW. Oral chronic graft-versus-host disease: current pathogenesis, therapy, and research. Oral Dis. 2013;19(4):327-46.
Hakim FT, Memon S, Jin P, Imanguli MM, Wang H, Rehman N, Yan XY, Rose J, Mays JW, Dhamala S, Kapoor V, Telford W, Dickinson J, Davis S, Halverson D, Naik HB, Baird K, Fowler D, Stroncek D, Cowen EW, Pavletic SZ, Gress RE. Upregulation of IFN-Inducible and Damage-Response Pathways in Chronic Graft-versus-Host Disease. J Immunol. 2016;197(9):3490-3503.
Mays JW, Carey BP, Posey R, Gueiros LA, France K, Setterfield J, Woo SB, Sollecito TP, Culton D, Payne AS, Greenberg MS, De Rossi S. World Workshop of Oral Medicine VII: A systematic review of immunobiologic therapy for oral manifestations of pemphigoid and pemphigus. Oral Dis. 2019;25 Suppl 1:111-121.
Mays JW, Powell ND, Hunzeker JT, Hanke ML, Bailey MT, Sheridan JF. Stress and the anti-influenza immune response: repeated social defeat augments clonal expansion of CD8(+)T cells during primary influenza A viral infection. J Neuroimmunol. 2012;243(1-2):34-42.
Hickman HD, Mays JW, Gibbs J, Kosik I, Magadán JG, Takeda K, Das S, Reynoso GV, Ngudiankama BF, Wei J, Shannon JP, McManus D, Yewdell JW. Influenza A Virus Negative Strand RNA Is Translated for CD8+ T Cell Immunosurveillance. J Immunol. 2018;201(4):1222-1228.
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This page was last updated on July 6th, 2021