Isabel Beerman, Ph.D.
Translational Gerontology / Epigenetics and Stem Cell Aging Unit
251 Bayview Boulevard
Baltimore, MD 21224
The Epigenetics and Stem Cell Aging Unit is focused on understanding mechanisms that underlie age-associated functional decline, with a focus on adult tissue-specific stem cells. By establishing the mechanisms leading to dysregulation of stem cells, we can begin to target these alterations to restore potential to the aging stem cell compartments. As the tissue-specific stem cells are responsible for maintaining overall tissue homeostasis, reestablishing the full potential to these aged cells could mitigate many aged associated phenotypes.
McNeely T, Leone M, Yanai H, Beerman I. DNA damage in aging, the stem cell perspective. Hum Genet. 2019.
Beerman I. Accumulation of DNA damage in the aged hematopoietic stem cell compartment. Semin Hematol. 2017;54(1):12-18.
Gutierrez-Martinez P, Hogdal L, Nagai M, Kruta M, Singh R, Sarosiek K, Nussenzweig A, Beerman I, Letai A, Rossi DJ. Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage. Nat Cell Biol. 2018;20(4):413-421.
Zhang Y, Charlton J, Karnik R, Beerman I, Smith ZD, Gu H, Boyle P, Mi X, Clement K, Pop R, Gnirke A, Rossi DJ, Meissner A. Targets and genomic constraints of ectopic Dnmt3b expression. Elife. 2018;7.
Scaramozza A, Park D, Kollu S, Beerman I, Sun X, Rossi DJ, Lin CP, Scadden DT, Crist C, Brack AS. Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress. Cell Stem Cell. 2019;24(6):944-957.e5.
Related Scientific Focus Areas
Genetics and Genomics
This page was last updated on August 1st, 2019