Isabel Beerman, Ph.D.

Stadtman Investigator

Translational Gerontology / Epigenetics and Stem Cell Aging Unit

NIA

View Site

Room 10C220
251 Bayview Boulevard
Baltimore, MD 21224

410-558-8600

Isabel.beerman@nih.gov

Research Topics

The Epigenetics and Stem Cell Aging Unit is focused on understanding mechanisms that underlie age-associated functional decline, with a focus on adult tissue-specific stem cells. By establishing the mechanisms leading to dysregulation of stem cells, we can begin to target these alterations to restore potential to the aging stem cell compartments. As the tissue-specific stem cells are responsible for maintaining overall tissue homeostasis, reestablishing the full potential to these aged cells could mitigate many aged associated phenotypes.

Selected Publications

  1. Yanai H, Park B, Koh H, Jang HJ, Vaughan KL, Tanaka-Yano M, Aon M, Blanton M, Messaoudi I, Diaz-Ruiz A, Mattison JA, Beerman I. Short-term periodic restricted feeding elicits metabolome-microbiome signatures with sex dimorphic persistence in primate intervention. Nat Commun. 2024;15(1):1088.
  2. Yanai H, McNeely T, Ayyar S, Leone M, Zong L, Park B, Beerman I. DNA methylation drives hematopoietic stem cell aging phenotypes after proliferative stress. Geroscience. 2025;47(2):1873-1886.
  3. Zong L, Tanaka-Yano M, Park B, Yanai H, Turhan FT, Croteau DL, Tian J, Fang EF, Bohr VA, Beerman I. NAD(+) augmentation with nicotinamide riboside improves lymphoid potential of Atm(-/-) and old mice HSCs. NPJ Aging Mech Dis. 2021;7(1):25.
  4. Culig L, Kashyap A, Kuribayashi W, Claybourne QC, Beerman I. Nicotinamide riboside treatment enhances stress sensitivity and modulates hematological dynamics in aged mice. Geroscience. 2025.
  5. Tanaka-Yano M, Zong L, Park B, Yanai H, Tekin-Turhan F, Blackshear PJ, Beerman I. Tristetraprolin overexpression drives hematopoietic changes in young and middle-aged mice generating dominant mitigating effects on induced inflammation in murine models. Geroscience. 2024;46(1):1271-1284.

Related Scientific Focus Areas

This page was last updated on Wednesday, August 20, 2025