Heinz Ulrich Feldmann, M.D., Ph.D.
Disease Modeling and Transmission Section
The Disease Modeling and Transmission Section was established in August 2008. Its mission is to study emerging and re-emerging viral pathogens, in particular those that cause hemorrhagic fever, with an aim of developing diagnostics, treatments, and vaccines. The section focuses on the lifecycle of certain viral pathogens that are likely to cause serious or lethal human disease for which preventive or therapeutic interventions are not available. The research objective is to learn how to interfere with the viral lifecycle and the virus-induced host responses to identify targets of intervention and to develop measures of prevention. Animal disease modeling is a critical component of all research objectives.
Heinz Feldmann graduated from medical school in 1987 (M.D.) and received his Ph.D. in 1988, both from the University of Marburg, Germany. His postdoctoral research was conducted in the field of virology (filoviruses and hantaviruses) at the Institute of Virology, University of Marburg, Germany, and the special pathogens branch at the Centers for Disease Control and Prevention in Atlanta, where he held a fellowship from the National Research Council. Following his postdoctoral training, he was as an assistant and associate professor with the Institute of Virology at the University of Marburg, Germany. During this time he was trained as an infectious disease specialist with a focus on laboratory diagnostics. From 1999 to 2008, Dr. Feldmann held the position of chief of the special pathogens program of the National Microbiology Laboratory, Public Health Agency of Canada. Since 2008, he has been the chief of Laboratory of Virology and the chief scientist at the RML BSL-4 laboratories. In addition, he is an associate professor with the department of medical microbiology, University of Manitoba. Dr. Feldmann is a laboratory expert on high containment viruses (BSL-4) and serves as a consultant on viral hemorrhagic fevers and related pathogens for the World Health Organization and, thus, has field experience and expertise in outbreak management. He is a member of national and international professional societies, and serves on the editorial board of several journals, as well as being an invited reviewer for multiple journals from related fields. Dr. Feldmann is an external scientific reviewer for national and international organizations and serves as a scientific consultant for high containment laboratories. His professional interest is in the pathogenesis of hemorrhagic fever viruses, such as filoviruses, arenaviruses and bunyaviruses, and other emerging viral pathogens (containment level BSL-3 and BSL-4) and the development of countermeasures against those pathogens.
- Hoenen T, Safronetz D, Groseth A, Wollenberg KR, Koita OA, Diarra B, Fall IS, Haidara FC, Diallo F, Sanogo M, Sarro YS, Kone A, Togo AC, Traore A, Kodio M, Dosseh A, Rosenke K, de Wit E, Feldmann F, Ebihara H, Munster VJ, Zoon KC, Feldmann H, Sow S. Virology. Mutation rate and genotype variation of Ebola virus from Mali case sequences. Science. 2015;348(6230):117-9.
- Marzi A, Reynolds P, Mercado-Hernandez R, Callison J, Feldmann F, Rosenke R, Thomas T, Scott DP, Hanley PW, Haddock E, Feldmann H. Single low-dose VSV-EBOV vaccination protects cynomolgus macaques from lethal Ebola challenge. EBioMedicine. 2019;49:223-231.
- Haddock E, Feldmann F, Hawman DW, Zivcec M, Hanley PW, Saturday G, Scott DP, Thomas T, Korva M, Avšič-Županc T, Safronetz D, Feldmann H. A cynomolgus macaque model for Crimean-Congo haemorrhagic fever. Nat Microbiol. 2018;3(5):556-562.
- Safronetz D, Prescott J, Feldmann F, Haddock E, Rosenke R, Okumura A, Brining D, Dahlstrom E, Porcella SF, Ebihara H, Scott DP, Hjelle B, Feldmann H. Pathophysiology of hantavirus pulmonary syndrome in rhesus macaques. Proc Natl Acad Sci U S A. 2014;111(19):7114-9.
- Hawman DW, Haddock E, Meade-White K, Nardone G, Feldmann F, Hanley PW, Lovaglio J, Scott D, Komeno T, Nakajima N, Furuta Y, Gowen BB, Feldmann H. Efficacy of favipiravir (T-705) against Crimean-Congo hemorrhagic fever virus infection in cynomolgus macaques. Antiviral Res. 2020:104858.
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Microbiology and Infectious Diseases
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This page was last updated on Saturday, August 8, 2020