Heather Hickman, Ph.D.
Laboratory of Viral Diseases
Building 33 Room 2E13
33 North Drive
Bethesda MD 20814
Generating protective antiviral immunity is a complex process that begins at the infection or vaccination site, amplifies in the regional draining lymph node, and culminates in the prevention or resolution of tissue infection. Rationally designed vaccines are based on maximizing beneficial cellular and humoral responses while minimizing overly zealous reactions causing host pathology.
To fully harness the power of the immune response, it is critical to understand not only the effector functions of lymphocytes, but also the anatomy of immune responses leading to host protection. For instance, the precise location of leukocytes in the skin determines whether permissive cells are accessible to vector-borne viruses; likewise, intradermal vaccines can be transported to the draining lymph node by skin-resident cells. Inside the lymph node, T-cells are primed in distinct microenvironments in processes that are incompletely understood. In peripheral tissues, little is known concerning the precise location and movement of immune effectors, including those of virus-specific T-cells or B-cells. The goal of the Immunity and Pathogenesis Unit is to generate a detailed understanding of immunity to viral infection and vaccination in lymphoid and peripheral tissues, with an emphasis on the role of the anatomy on immunity.
Antiviral T-cells (red) surround vaccinia-virus infected cells in the skin five days after infection using a bifurcated needle. This image was acquired using intravital multiphoton microscopy; the dermis of the skin is indicated by the presence of collagen (blue, second harmonic generation signal).
Dr. Heather Hickman received her Ph.D. (Microbiology and Immunology) from the University of Oklahoma Health Sciences Center in 2003. While training in the lab of Dr. William Hildebrand, she investigated the presentation of viral ligands by major histocompatibility class I molecules. In 2004, she joined the Laboratory of Viral Diseases (LVD) (NIAID), first as a postdoctoral fellow with Dr. Jonathan Yewdell and later as a senior associate scientist. In the LVD, Dr. Hickman developed a research program aimed at better defining the mechanisms of adaptive immunity to viral infections using a number of different viruses as models (such as vaccinia, Zika, and influenza). Dr. Hickman became an Earl-Stadtman tenure-track investigator in the Viral Immunity and Pathogenesis Unit in 2017.
Hickman HD. New insights into antiviral immunity gained through intravital imaging. Curr Opin Virol. 2017;22:59-63.
Cush SS, Reynoso GV, Kamenyeva O, Bennink JR, Yewdell JW, Hickman HD. Locally Produced IL-10 Limits Cutaneous Vaccinia Virus Spread. PLoS Pathog. 2016;12(3):e1005493.
McCarthy MK, Davenport BJ, Reynoso GV, Lucas ED, May NA, Elmore SA, Tamburini BA, Hickman HD, Morrison TE. Chikungunya virus impairs draining lymph node function by inhibiting HEV-mediated lymphocyte recruitment. JCI Insight. 2018;3(13).
Hickman HD, Mays JW, Gibbs J, Kosik I, Magádan JG, Takeda K, Das S, Reynoso GV, Ngudiankama BF, Wei J, Shannon JP, McManus D, Yewdell JW. Influenza A Virus Negative Strand RNA Is Translated for CD8<sup>+</sup> T Cell Immunosurveillance. J Immunol. 2018.
Beura LK, Mitchell JS, Thompson EA, Schenkel JM, Mohammed J, Wijeyesinghe S, Fonseca R, Burbach BJ, Hickman HD, Vezys V, Fife BT, Masopust D. Intravital mucosal imaging of CD8<sup>+</sup> resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory. Nat Immunol. 2018;19(2):173-182.
Related Scientific Focus Areas
Microbiology and Infectious Diseases
This page was last updated on August 6th, 2018