Guohong Cui, M.D., Ph.D.

Senior Investigator

Neurobiology Laboratory / In Vivo Neurobiology Group


David P Rall Building
111 Tw Alexander Dr
Research Triangle Park, NC 27709


Research Topics

Guohong Cui, M.D., Ph.D., leads the In Vivo Neurobiology Group in the NIEHS Neurobiology Laboratory and holds a secondary appointment in the NIEHS Reproductive and Developmental Biology Laboratory. His group studies voluntary movements in healthy animals and in animal models of neurological disorders. They try to synthesize task-specific neural activity maps by monitoring and manipulating molecular and cellular events in genetically defined groups of neurons in behaving animals. Their current research is focused on how dopamine impacts the activity of the basal ganglia circuits in vivo. They are also looking for treatments that can slow down the progressive loss of dopamine neurons in various mouse models of Parkinson's disease.


Dr. Cui received his M.D. from Peking University Health Science Center in 1998 and a Ph.D. in neuroscience from The University of Texas at Austin in 2007. He was a postdoc fellow at the National Institute on Alcohol Abuse and Alcoholism. He came to NIEHS as a tenure-track investigator in 2014.

Selected Publications

  1. Zhou J, Li J, Papaneri AB, Kobzar NP, Cui G. Dopamine Neuron Challenge Test for early detection of Parkinson's disease. NPJ Parkinsons Dis. 2021;7(1):116.
  2. Sun F, Zhou J, Dai B, Qian T, Zeng J, Li X, Zhuo Y, Zhang Y, Wang Y, Qian C, Tan K, Feng J, Dong H, Lin D, Cui G, Li Y. Next-generation GRAB sensors for monitoring dopaminergic activity in vivo. Nat Methods. 2020;17(11):1156-1166.
  3. Mazzone CM, Liang-Guallpa J, Li C, Wolcott NS, Boone MH, Southern M, Kobzar NP, Salgado IA, Reddy DM, Sun F, Zhang Y, Li Y, Cui G, Krashes MJ. High-fat food biases hypothalamic and mesolimbic expression of consummatory drives. Nat Neurosci. 2020;23(10):1253-1266.
  4. Meng C, Zhou J, Papaneri A, Peddada T, Xu K, Cui G. Spectrally Resolved Fiber Photometry for Multi-component Analysis of Brain Circuits. Neuron. 2018;98(4):707-717.e4.
  5. Cui G, Jun SB, Jin X, Pham MD, Vogel SS, Lovinger DM, Costa RM. Concurrent activation of striatal direct and indirect pathways during action initiation. Nature. 2013;494(7436):238-42.

Related Scientific Focus Areas

This page was last updated on Thursday, March 5, 2015