Guohong Cui, M.D., Ph.D.
Neurobiology Laboratory / In Vivo Neurobiology Group
F175 Rall Building
111 T W Alexander Dr
Research Triangle Park, NC 27709
Guohong Cui, M.D., Ph.D., leads the In Vivo Neurobiology Group in the NIEHS Neurobiology Laboratory and holds a secondary appointment in the NIEHS Reproductive and Developmental Biology Laboratory. His group studies voluntary movements in healthy animals and in animal models of neurological disorders. They try to synthesize task-specific neural activity maps by monitoring and manipulating molecular and cellular events in genetically defined groups of neurons in behaving animals. Their current research is focused on how dopamine impacts the activity of the basal ganglia circuits in vivo. They are also looking for treatments that can slow down the progressive loss of dopamine neurons in various mouse models of Parkinson's disease.
Dr. Cui received his M.D. from Peking University Health Science Center in 1998 and a Ph.D. in neuroscience from The University of Texas at Austin in 2007. He was a postdoc fellow at the National Institute on Alcohol Abuse and Alcoholism. He came to NIEHS as a tenure-track investigator in 2014.
Feng J, Zhang C, Lischinsky JE, Jing M, Zhou J, Wang H, Zhang Y, Dong A, Wu Z, Wu H, Chen W, Zhang P, Zou J, Hires SA, Zhu JJ, Cui G, Lin D, Du J, Li Y. A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine. Neuron. 2019;102(4):745-761.e8.
Sun F, Zeng J, Jing M, Zhou J, Feng J, Owen SF, Luo Y, Li F, Wang H, Yamaguchi T, Yong Z, Gao Y, Peng W, Wang L, Zhang S, Du J, Lin D, Xu M, Kreitzer AC, Cui G, Li Y. A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice. Cell. 2018;174(2):481-496.e19.
Meng C, Zhou J, Papaneri A, Peddada T, Xu K, Cui G. Spectrally Resolved Fiber Photometry for Multi-component Analysis of Brain Circuits. Neuron. 2018;98(4):707-717.e4.
Cui G, Jun SB, Jin X, Luo G, Pham MD, Lovinger DM, Vogel SS, Costa RM. Deep brain optical measurements of cell type-specific neural activity in behaving mice. Nat Protoc. 2014;9(6):1213-28.
Cui G, Jun SB, Jin X, Pham MD, Vogel SS, Lovinger DM, Costa RM. Concurrent activation of striatal direct and indirect pathways during action initiation. Nature. 2013;494(7436):238-42.
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This page was last updated on March 5th, 2015