Grégoire Altan-Bonnet, Ph.D.

Senior Investigator

Laboratory of Integrative Cancer Immunology

NCI/CCR

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Building 37, Room 4134
Bethesda, MD 20892

240-760-6888

gregoire.altan-bonnet@nih.gov

Research Topics

We are interested in developing actionable models of the immune response to design and optimize new immunotherapies. Our premise is that the immune system is a self-organized collection of cells, whose individual activation must be harnessed, tuned, and coaxed at the population level. We rely on new quantitative methods (e.g., single-cell phosphoprofiling by FACS and CyTOF) and computational modeling to identify key limiting steps controlling the balance between response and tolerance in the immune system.

Our computational models are strongly interfaced with our experimental efforts. We model immunological events explicitly, starting from biochemical events (e.g., ligand/receptor interactions) to cellular (signal transduction and gene regulation) to population dynamics. Such integration of multiple spatial- and time-scales is leading to a better understanding of the dynamics of immune responses, and is opening new opportunities for external manipulation and immunotherapies. Our projects go from conceptual and fundamental aspects of the immune system, to very practical applications in the pre-clinical context (profiling of tumors, manipulation of immune responses against tumors).

Biography

1992-1994 Bachelor of Science (Physics) - École Normale Supérieure (Paris, France)
1994-1995 Master of Science (Physics) - École Normale Supérieure (Lyon, France)
1995-2000 Ph.D. (Physics) - the Rockefeller University (New York, NY)
2000-2005 Research Fellow (post-doctoral studies) - Laboratory of Immunology, NIAID (Bethesda, MD)
2005-2011 Assistant member - Computational Biology & Immunology programs - Memorial Sloan Kettering (New York, NY)
2012-2015 Associate member - Computational Biology & Immunology programs - Memorial Sloan Kettering (New York, NY)
2016-2020 Earl Stadtman Investigator - Laboratory of Integrative Cancer Immunology (formerly, Cancer and Inflammation Program), Center for Cancer Research, NCI (Bethesda, MD) 2020-present Senior Investigator (tenured) - Laboratory of Integrative Cancer Immunology, Center for Cancer Research, NCI (Bethesda, MD)

Selected Publications

  1. Altan-Bonnet G, Mukherjee R. Cytokine-mediated communication: a quantitative appraisal of immune complexity. Nat Rev Immunol. 2019;19(4):205-217.
  2. Ziegler CGK, Kim J, Piersanti K, Oyler-Yaniv A, Argyropoulos KV, van den Brink MRM, Palomba ML, Altan-Bonnet N, Altan-Bonnet G. Constitutive Activation of the B Cell Receptor Underlies Dysfunctional Signaling in Chronic Lymphocytic Leukemia. Cell Rep. 2019;28(4):923-937.e3.
  3. Oyler-Yaniv A, Oyler-Yaniv J, Whitlock BM, Liu Z, Germain RN, Huse M, Altan-Bonnet G, Krichevsky O. A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System. Immunity. 2017;46(4):609-620.
  4. Oyler-Yaniv J, Oyler-Yaniv A, Shakiba M, Min NK, Chen YH, Cheng SY, Krichevsky O, Altan-Bonnet N, Altan-Bonnet G. Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation. Mol Cell. 2017;66(5):635-647.e7.
  5. Erez A, Altan-Bonnet G. Lymphocytic division clocked up by Myc. Immunol Cell Biol. 2017;95(2):119-120.

Related Scientific Focus Areas

This page was last updated on Thursday, February 22, 2024