Gisela T. Storz, Ph.D.
NIH Distinguished Investigator
Section on Environmental Gene Regulation
Building 18, Room 113
9000 Rockville Pike
Bethesda, MD 20892
Currently, we have two main interests: the identification and characterization of small noncoding RNAs and the identification and characterization of small proteins of less than 50 amino acids. For two reasons, small RNAs and small proteins have been overlooked. First, biochemical assays do not detect these small molecules. Second, genome annotation misses the corresponding genes, which are poor targets for genetic approaches. However, mounting evidence suggests that both classes of these small molecules play important regulatory roles.
Guo MS, Updegrove TB, Gogol EB, Shabalina SA, Gross CA, Storz G. MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein. Genes Dev. 2014;28(14):1620-34.
Updegrove TB, Shabalina SA, Storz G. How do base-pairing small RNAs evolve? FEMS Microbiol Rev. 2015;39(3):379-91.
Dambach M, Sandoval M, Updegrove TB, Anantharaman V, Aravind L, Waters LS, Storz G. The ubiquitous yybP-ykoY riboswitch is a manganese-responsive regulatory element. Mol Cell. 2015;57(6):1099-109.
Storz G, Wolf YI, Ramamurthi KS. Small proteins can no longer be ignored. Annu Rev Biochem. 2014;83:753-77.