Giovanna Tosato, M.D.
Laboratory of Cellular Oncology
Building 37, Room 4124B
Bethesda, MD 20892-1906
The laboratory focuses on the study of the endothelium in the context of cancer development and progression. We study new vessel formation (angiogenesis) and vessel survival as these processes are essential for tumor growth. We investigate the endothelium as a component of the hematopoietic cell niche, which regulates stem cell maintenance and hematopoiesis, as hematopoietic cell populations regulate tumor development and progression. We seek to use information from this research to develop targeted therapies for cancer and other conditions in which the endothelium plays a functional role. Malignancies associated with EBV and/or KSHV infection are of particular interest as these herpes viruses can infect endothelial cells contributing to tumor development.
Dr. Tosato attended the La Sapienza Medical School in Rome, Italy, where she received her M.D. in 1973 and completed her residency in medicine at the Catholic University in Rome. In 1976, she came to the NCI where she became a Clinical Associate in the Pediatric and Medicine Branches and subsequently a visiting fellow in the Metabolism Branch. In 1983, Dr. Tosato began working at the Food and Drug Administration. From 1992-99 she served as Director, Division of Hematologic Products, Center for Biologics Evaluation and Research, FDA. In 1999 Dr. Tosato returned to the NCI as a senior investigator.
Tosato G, Magrath I, Koski I, Dooley N, Blaese M. Activation of suppressor T cells during Epstein-Barr-virus-induced infectious mononucleosis. N Engl J Med. 1979;301(21):1133-7.
Tosato G, Seamon KB, Goldman ND, Sehgal PB, May LT, Washington GC, Jones KD, Pike SE. Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6). Science. 1988;239(4839):502-4.
Nakayama T, Mutsuga N, Tosato G. Effect of fibroblast growth factor 2 on stromal cell-derived factor 1 production by bone marrow stromal cells and hematopoiesis. J Natl Cancer Inst. 2007;99(3):223-35.
Segarra M, Ohnuki H, Maric D, Salvucci O, Hou X, Kumar A, Li X, Tosato G. Semaphorin 6A regulates angiogenesis by modulating VEGF signaling. Blood. 2012;120(19):4104-15.
Related Scientific Focus Areas
Microbiology and Infectious Diseases
Molecular Biology and Biochemistry
This page was last updated on September 13th, 2019