Geoffrey Schoenbaum, M.D., Ph.D.
NIH Distinguished Investigator
Cellular and Neurocomputational Systems Branch, Behavioral Neurophysiology Neuroscience Section
Our lab is interested in the neural circuits mediating associative learning and decision making and how alterations in those circuits contribute to maladaptive behaviors in neuropsychiatric disorders such as addiction. We use rats as a model system to study behaviors and neural circuits that we believe have direct relevance to understanding the human brain. Areas of particular interest include the orbitofrontal cortex, amygdala, striatum, and midbrain dopamine system. Our lab uses behavioral tasks based on principles derived from learning theory, combined with single unit recording, lesions, pharmacological and genetic manipulations to test hypotheses about how these areas interact to support learning and adaptive behavior.
- Gardner MPH, Schoenbaum G. The orbitofrontal cartographer. Behav Neurosci. 2021;135(2):267-276.
- Sharpe MJ, Chang CY, Liu MA, Batchelor HM, Mueller LE, Jones JL, Niv Y, Schoenbaum G. Dopamine transients are sufficient and necessary for acquisition of model-based associations. Nat Neurosci. 2017;20(5):735-742.
- Takahashi YK, Batchelor HM, Liu B, Khanna A, Morales M, Schoenbaum G. Dopamine Neurons Respond to Errors in the Prediction of Sensory Features of Expected Rewards. Neuron. 2017;95(6):1395-1405.e3.
- Zhou J, Jia C, Montesinos-Cartagena M, Gardner MPH, Zong W, Schoenbaum G. Evolving schema representations in orbitofrontal ensembles during learning. Nature. 2021;590(7847):606-611.
- Lucantonio F, Takahashi YK, Hoffman AF, Chang CY, Bali-Chaudhary S, Shaham Y, Lupica CR, Schoenbaum G. Orbitofrontal activation restores insight lost after cocaine use. Nat Neurosci. 2014;17(8):1092-9.
Related Scientific Focus Areas
Social and Behavioral Sciences
View additional Principal Investigators in Social and Behavioral Sciences
This page was last updated on Friday, November 2, 2018