Freddy E. Escorcia, M.D., Ph.D.
Lasker Clinical Research Scholar
Molecular Imaging Branch
Building 10 Room 1B55 Bethesda, MD 20892
Advances in engineering of tumor-specific molecules to guide cytotoxic treatments, such as chemotherapy or radionuclides, have resulted in new classes of cancer drugs which have the potential to kill tumors while mitigating toxicities to normal tissues, moving us closer to truly tumor-targeted, personalized cancer treatment for our patients. Targeted radionuclide therapy provides an orthogonal mode of cell killing that is distinct from, yet complementary to, existing small molecule and chemotherapy treatments. By harnessing systemic, targeted radionuclides, our group aims to develop new agents to help us better treat and monitor cancer patients. Dr. Escorcia is also a clinically trained radiation oncologist and treats patients with all tumor types amenable to radiation therapy.
Dr. Escorcia’s journey began in a small coastal town on the Atlantic side of Nicaragua, continued through to Toronto, Ontario, then to central Illinois. He earned his undergraduate degrees in bioengineering and chemistry at the University of Illinois at Urbana-Champaign, igniting his interest in science and medicine, and prompting enrollment in the Tri-Institutional M.D./Ph.D. Program of Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC) and Rockefeller University in New York, NY. Dr. Escorcia’s thesis work involved engineering tumor-targeted antibodies and polymers to delivery cytotoxic alpha-particle radionuclide payloads. This experience with harnessing radiation for cancer therapy led to Dr. Escorcia’s pursuit of a radiation oncology residency at MSKCC and continues to drive his research and clinical interests as an Assistant Clinical Investigator within the Molecular Imaging Branch and the Radiation Oncology Branch at NCI's Center for Cancer Research. Dr. Escorcia enjoys working with and learning from trainees, recently earning a Distinguished Mentor Award. Outside of the lab Dr. Escorcia is enjoys traveling, reading, weight training, and spending time with his family.
Escorcia FE, Postow MA, Barker CA. Radiotherapy and Immune Checkpoint Blockade for Melanoma: A Promising Combinatorial Strategy in Need of Further Investigation. Cancer J. 2017;23(1):32-39.
Mulvey JJ, Villa CH, McDevitt MR, Escorcia FE, Casey E, Scheinberg DA. Self-assembly of carbon nanotubes and antibodies on tumours for targeted amplified delivery. Nat Nanotechnol. 2013;8(10):763-71.
Scheinberg DA, Villa CH, Escorcia FE, McDevitt MR. Conscripts of the infinite armada: systemic cancer therapy using nanomaterials. Nat Rev Clin Oncol. 2010;7(5):266-76.
Escorcia FE, Henke E, McDevitt MR, Villa CH, Smith-Jones P, Blasberg RG, Benezra R, Scheinberg DA. Selective killing of tumor neovasculature paradoxically improves chemotherapy delivery to tumors. Cancer Res. 2010;70(22):9277-86.
Massé E, Escorcia FE, Gottesman S. Coupled degradation of a small regulatory RNA and its mRNA targets in Escherichia coli. Genes Dev. 2003;17(19):2374-83.
Related Scientific Focus Areas
Biomedical Engineering and Biophysics
Molecular Biology and Biochemistry
This page was last updated on September 1st, 2021