Freddy E. Escorcia, M.D., Ph.D.

Assistant Clinical Investigator

Molecular Imaging Branch


Building 10 Room 1B55
Bethesda, MD 20892


Research Topics

Advances in engineering of tumor-specific molecules to guide cytotoxic treatments, such as chemotherapy or radionuclides, have resulted in new classes of cancer drugs which have the potential to kill tumors while mitigating toxicities to normal tissues, moving us closer to truly tumor-targeted, personalized cancer treatment for our patients.  Targeted radionuclide therapy provides an orthogonal mode of cell killing that is distinct from, yet complementary to, existing small molecule and chemotherapy treatments. By harnessing systemic, targeted radionuclides, our group aims to develop new agents to help us better treat and monitor cancer patients. Dr. Escorcia is also a clinically trained radiation oncologist and treats patients with all tumor types amenable to radiation therapy.


Dr. Escorcia’s thirst for learning began in a small coastal town on the Atlantic side of Nicaragua, continued through to Toronto, Ontario, then to central Illinois. He earned his undergraduate degrees in bioengineering and chemistry at the University of Illinois at Urbana-Champaign, igniting his interest in science and medicine, and prompting enrollment in the Tri-Institutional M.D./Ph.D. Program of Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center (MSKCC) and Rockefeller University in New York, NY. Dr. Escorcia’s thesis work involved engineering tumor-targeted antibodies and polymers to delivery cytotoxic alpha-particle radionuclide payloads. This experience with harnessing radiation for cancer therapy led to Dr. Escorcia’s pursuit of a radiation oncology residency at MSKCC and continues to drive his research and clinical interests as an Assistant Clinical Investigator within the Molecular Imaging Program and the Radiation Oncology Branch at NCI's Center for Cancer Research. In 2019, Dr. Escorcia received the Distinguished Mentor Award.

Selected Publications

  1. Escorcia FE, Postow MA, Barker CA. Radiotherapy and Immune Checkpoint Blockade for Melanoma: A Promising Combinatorial Strategy in Need of Further Investigation. Cancer J. 2017;23(1):32-39.

  2. Mulvey JJ, Villa CH, McDevitt MR, Escorcia FE, Casey E, Scheinberg DA. Self-assembly of carbon nanotubes and antibodies on tumours for targeted amplified delivery. Nat Nanotechnol. 2013;8(10):763-71.

  3. Scheinberg DA, Villa CH, Escorcia FE, McDevitt MR. Conscripts of the infinite armada: systemic cancer therapy using nanomaterials. Nat Rev Clin Oncol. 2010;7(5):266-76.

  4. Escorcia FE, Henke E, McDevitt MR, Villa CH, Smith-Jones P, Blasberg RG, Benezra R, Scheinberg DA. Selective killing of tumor neovasculature paradoxically improves chemotherapy delivery to tumors. Cancer Res. 2010;70(22):9277-86.

  5. Massé E, Escorcia FE, Gottesman S. Coupled degradation of a small regulatory RNA and its mRNA targets in Escherichia coli. Genes Dev. 2003;17(19):2374-83.

This page was last updated on October 14th, 2020