Frank I. Lin, M.D.

Lasker Clinical Research Scholar

Molecular Imaging Branch

NCI/CCR

Building 10, Room 13C442
Bethesda, MD 20892-1088

240-760-6166

frank.lin2@nih.gov

Research Topics

The vision of the Targeted Radionuclide Therapy Section is to accelerate the development and clinical translation of novel radionuclide therapy as a treatment modality for cancer. Dr. Lin is interested in and investigates a number of different radionuclides in both clinical and pre-clinical settings, but is particularly interested in somatostatin receptor-positive rare tumors. In addition to agent development and research, Dr. Lin is also involved in the promotion and advancement of the field of radionuclide therapy, including educational pursuits such as the training of future medical practitioners of this promising form of therapy.

Biography

Dr. Lin completed his undergraduate work in Biological Sciences at Stanford University and has a Masters degree in Medical Informatics from the University of Utah. After receiving his medical degree from the Medical College of Wisconsin, Dr. Lin pursued training in various fields and is currently board-certified in Nuclear Medicine, Internal Medicine, and Medical Oncology. Dr. Lin has worked at the NCI since 2010, and was selected as a Lasker Clinical Research Scholar in 2016 to be the head of the newly created Targeted Radionuclide Therapy Section housed within the Molecular Imaging Branch headed by Dr. Peter Choyke. Dr. Lin’s research focuses on the translational and clinical evaluation of novel targeted radionuclide therapies to treat cancers, with special interest in somatostatin receptor-positive rare tumors such as pheochromocytomas/paragangliomas and gastroenteropancreatic GI neuroendocrine tumors. He is also very interested in methods to optimize radionuclide therapy approaches using strategies such as combination treatments and radiation dosimetry.

Selected Publications

  1. Janssen I, Chen CC, Zhuang Z, Millo CM, Wolf KI, Ling A, Lin FI, Adams KT, Herscovitch P, Feelders RA, Fojo AT, Taieb D, Kebebew E, Pacak K. Functional Imaging Signature of Patients Presenting with Polycythemia/Paraganglioma Syndromes. J Nucl Med. 2017;58(8):1236-1242.
  2. Lin FI, Gonzalez EM, Kummar S, Do K, Shih J, Adler S, Kurdziel KA, Ton A, Turkbey B, Jacobs PM, Bhattacharyya S, Chen AP, Collins JM, Doroshow JH, Choyke PL, Lindenberg ML. Utility of 18F-fluoroestradiol (18F-FES) PET/CT imaging as a pharmacodynamic marker in patients with refractory estrogen receptor-positive solid tumors receiving Z-endoxifen therapy. Eur J Nucl Med Mol Imaging. 2017;44(3):500-508.
  3. Janssen I, Chen CC, Millo CM, Ling A, Taieb D, Lin FI, Adams KT, Wolf KI, Herscovitch P, Fojo AT, Buchmann I, Kebebew E, Pacak K. PET/CT comparing (68)Ga-DOTATATE and other radiopharmaceuticals and in comparison with CT/MRI for the localization of sporadic metastatic pheochromocytoma and paraganglioma. Eur J Nucl Med Mol Imaging. 2016;43(10):1784-91.

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This page was last updated on Thursday, September 17, 2026