Francesco Demayo, Ph.D.
Reproductive and Developmental Biology Laboratory / Pregnancy and Female Reproduction Group
C422 Rall Building
111 T W Alexander Dr
Research Triangle Park, NC 27709
Understanding the molecular mechanisms regulating normal physiology and disease development in the uterus and lung is critical in understanding causes and treatments for reproductive and pulmonary disorders. In the investigation of the regulation of reproductive biology we have focused on major regulators of female reproductive tract homeostasis, the ovarian steroids progesterone and estrogen. Utilizing genetically engineered mouse models, high content transcriptomic and cistromic analysis along with primary human samples we have sought to understand the factors that: Regulate the preparation of the uterus for embryo implantation;. Allow the uterus to support embryo invasion and fetal growth and allow the uterus to deliver the fetus at the appropriate time during pregnancy. Towards these goals we have identified the paracrine signaling pathways that regulate uterine epithelial-stroma crosstalk in controlling uterine epithelial cell proliferation and receptivity for embryo attachment. We have identified the role of nuclear receptors and transcription factors governing differentiation of human endometrial stroma cells during pregnancy and have begun identifying the role of progesterone in the regulation of myometrial function. In the process we have generate several models for infertility and endometrial cancer. Our investigation of pulmonary biology have recently focused on understanding the molecular events regulating the progression and metastasis of lung cancer. In the process we have created several genetically engineered mouse models for the various types of lung cancer. The goal of establishing these in vivo models will serve as biosensors to understand how the environment interacts with specific molecular pathways in modulating normal physiology and disease development.
Francesco J. DeMayo is Senior Principal Investigator and Chief of the Reproduction and Developmental Biology Laboratory. He received his B.S. in General Studies at Cornell University and his M.S. and Ph.D in Physiology at Michigan State University. He continued his postdoctoral training at Baylor College of Medicine where rose to the rank of Cullen-Duncan-McAshan Endowed Chair in Cancer Research, and Professor of Molecular and Cell Biology and Pediatrics. During his tenure at Baylor College of Medicine he has received the Michael E DeBakey Research Award and the Society for the Study of Reproduction Research Award.
Kelleher AM, Peng W, Pru JK, Pru CA, DeMayo FJ, Spencer TE. Forkhead box a2 (FOXA2) is essential for uterine function and fertility. Proc Natl Acad Sci U S A. 2017;114(6):E1018-E1026.
Wetendorf M, Wu SP, Wang X, Creighton CJ, Wang T, Lanz RB, Blok L, Tsai SY, Tsai MJ, Lydon JP, DeMayo FJ. Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment. Biol Reprod. 2017;96(2):313-326.
Rubel CA, Wu SP, Lin L, Wang T, Lanz RB, Li X, Kommagani R, Franco HL, Camper SA, Tong Q, Jeong JW, Lydon JP, DeMayo FJ. A Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function. Cell Rep. 2016;17(5):1414-1425.
Vasquez YM, Wu SP, Anderson ML, Hawkins SM, Creighton CJ, Ray M, Tsai SY, Tsai MJ, Lydon JP, DeMayo FJ. Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis. Mol Endocrinol. 2016;30(5):518-32.
Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng GS, Xia G, Lu Z, Wang C, Wang H. Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 2017;114(18):4816-4821.
Related Scientific Focus Areas
Molecular Biology and Biochemistry
This page was last updated on October 12th, 2017