Eric A. Engels, M.D., M.P.H
Infections and Immunoepidemiology Branch
9609 Medical Center Drive
Rockville, MD 20850
Immunosuppression, Infection, and Inflammation in Cancer
A major focus of investigation concerns the epidemiology of cancer in immunosuppressed individuals. My research on HIV-related cancers utilizes data from our HIV/AIDS Cancer Match (HACM) Study. This study links HIV/AIDS and cancer registry data from 15 U.S. regions to identify cancers arising in over 650,000 people registered with HIV/AIDS. The HACM Study allows my colleagues and me to address important research questions and examine patterns of cancer incidence that have direct public health relevance. We have used this resource to characterize trends in cancer risk among people with AIDS over the entire course of the AIDS epidemic. Our studies have documented substantial declines in Kaposi sarcoma and non-Hodgkin lymphoma over time, and a rise in the risk of anal cancer. These cancer trends are part of a more general shift that we have documented, moving from AIDS-related cancers to other malignancies, as HIV-infected people age.
My coworkers and I also conduct research on cancer in solid organ transplant recipients, another immunosuppressed population. We have conducted a computerized match of the U.S. transplant registry with 16 cancer registries. This Transplant Cancer Match Study includes population-based cancer data on approximately half of the U.S. transplant population. This research is conducted in close collaboration with colleagues at the Health Resources and Services Administration (HRSA), which oversees the U.S. transplant network. Using these data, we have described the overall spectrum of cancer risk in transplant recipients, and we are doing further research projects focused on specific cancers and transplant-related risk factors.
An additional research interest in non-Hodgkin lymphoma stems from the high risk seen in people with HIV/AIDS, as well as my belief that other infections and immune-related conditions are important. My collaborators and I conducted a large retrospective cohort study of hepatitis C virus and risk of lymphoproliferative malignancies in U.S. military veterans. We demonstrated an association between chronic hepatitis B virus infection and an increased risk of non-Hodgkin lymphoma in a large Korean cohort. We have also described the impact of HIV on the burden of non-Hodgkin lymphoma in the U.S., and documented the risk of specific subtypes of non-Hodgkin lymphoma in both HIV-infected people and transplant recipients.
Dr. Engels earned a B.A. in mathematics from the University of Virginia in 1987 and an M.D. from Harvard Medical School in 1991. From 1991 to 1994, he trained in internal medicine at Brigham and Women's Hospital. Subsequently, Dr. Engels received clinical training in infectious diseases and an M.P.H. at Tufts University School of Medicine. He joined the NCI Viral Epidemiology Branch (later the Infections and Immunoepidemiology Branch (IIB)) in 1998 as a senior staff fellow, became an investigator in 2000, and was tenured in 2007. He was appointed Chief of IIB in 2017. Dr. Engels holds an adjunct faculty appointment in the Department of Epidemiology at the Johns Hopkins School of Public Health.
Engels EA, Pfeiffer RM, Fraumeni JF Jr, Kasiske BL, Israni AK, Snyder JJ, Wolfe RA, Goodrich NP, Bayakly AR, Clarke CA, Copeland G, Finch JL, Fleissner ML, Goodman MT, Kahn A, Koch L, Lynch CF, Madeleine MM, Pawlish K, Rao C, Williams MA, Castenson D, Curry M, Parsons R, Fant G, Lin M. Spectrum of cancer risk among US solid organ transplant recipients. JAMA. 2011;306(17):1891-901.
Robbins HA, Pfeiffer RM, Shiels MS, Li J, Hall HI, Engels EA. Excess cancers among HIV-infected people in the United States. J Natl Cancer Inst. 2015;107(4).
Shiels MS, Pfeiffer RM, Hall HI, Li J, Goedert JJ, Morton LM, Hartge P, Engels EA. Proportions of Kaposi sarcoma, selected non-Hodgkin lymphomas, and cervical cancer in the United States occurring in persons with AIDS, 1980-2007. JAMA. 2011;305(14):1450-9.
Gibson TM, Morton LM, Shiels MS, Clarke CA, Engels EA. Risk of non-Hodgkin lymphoma subtypes in HIV-infected people during the HAART era: a population-based study. AIDS. 2014;28(15):2313-8.
Chang CM, Stapleton JT, Klinzman D, McLinden JH, Purdue MP, Katki HA, Engels EA. GBV-C infection and risk of NHL among U.S. adults. Cancer Res. 2014;74(19):5553-60.
Related Scientific Focus Areas
Genetics and Genomics
This page was last updated on November 7th, 2018