Edward G. Lakatta, M.D.

Senior Investigator

Laboratory of Cardiovascular Science

NIA

251 Bayview Boulevard
Suite 100
Baltimore, MD 21224

410-558-8202

lakattae@mail.nih.gov

Research Topics

The overall goals of the Laboratory of Cardiovascular Science are (1) to identify age-associated changes that occur within the cardiovascular system and to determine the mechanisms for these changes; (2) to study myocardial structure and function and to determine how age interacts with chronic disease states to alter function; (3) to study basic mechanisms in excitation-contraction coupling and how these are modulated by surface receptor signaling pathways in cardiac muscle; (4) to determine the chemical nature and sequence of intermediate reactions controlling the movement of ions through ionic channels and pumps present in myocardium, and how these are affected by aging and disease; (5) to determine mechanisms that govern neuro-hormonal behavioral aspects of hypertension; (6) to determine mechanisms of normal and abnormal function of vascular smooth muscle and endothelial cells; and (7) to establish the potentials and limitations of new therapeutic approaches such as gene transfer techniques. In meeting these objectives, studies are performed in human volunteers, intact animals, isolated heart and vascular tissues, isolated cardiac and vascular cells, and subcellular organelles.

Biography

Dr. Lakatta received his M.D. from Georgetown University School of Medicine, Washington, D.C. in 1970. His postdoctoral training included an internship and residency in medicine at Strong Memorial Hospital, University of Rochester School of Medicine, cardiology fellowships at Georgetown and Johns Hopkins University Hospitals, and basic research training at NIH and at the Department of Physiology, University College, London, England. He was section chief of the Cardiovascular Laboratory in the Clinical Physiology Branch from 1976 to 1985, at which time he founded the Laboratory of Cardiovascular Science.

Selected Publications

  1. Tagirova Sirenko S, Tsutsui K, Tarasov KV, Yang D, Wirth AN, Maltsev VA, Ziman BD, Yaniv Y, Lakatta EG. Self-Similar Synchronization of Calcium and Membrane Potential Transitions During Action Potential Cycles Predict Heart Rate Across Species. JACC Clin Electrophysiol. 2021.

  2. Tsutsui K, Florio MC, Yang A, Wirth AN, Yang D, Kim MS, Ziman BD, Bychkov R, Monfredi OJ, Maltsev VA, Lakatta EG. cAMP-Dependent Signaling Restores AP Firing in Dormant SA Node Cells via Enhancement of Surface Membrane Currents and Calcium Coupling. Front Physiol. 2021;12:596832.

  3. AlGhatrif M, Morrell CH, Becker LC, Chantler PD, Najjar SS, Ferrucci L, Gerstenblith G, Lakatta EG. Longitudinal uncoupling of the heart and arteries with aging in a community-dwelling population. Geroscience. 2021;43(2):551-561.

  4. Bychkov R, Juhaszova M, Tsutsui K, Coletta C, Stern MD, Maltsev VA, Lakatta EG. Synchronized Cardiac Impulses Emerge From Heterogeneous Local Calcium Signals Within and Among Cells of Pacemaker Tissue. JACC Clin Electrophysiol. 2020;6(8):907-931.

  5. Axsom JE, Nanavati AP, Rutishauser CA, Bonin JE, Moen JM, Lakatta EG. Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice. Geroscience. 2020;42(1):217-232.


This page was last updated on September 1st, 2021