Research Topics
Dr. Cowen's primary interests include chronic graft-versus-host disease (GVHD), primary immunodeficiency, autoinflammatory skin disease, cancer genodermatoses, and adverse drug reactions. Dr. Cowen has authored more than 200 original manuscripts and chapters. Novel discoveries include the first identification of total body irradiation as a risk factor for skin fibrosis in chronic GVHD, and the first comprehensive series describing angiomatosis, calcinosis, and alopecia areata and vitiligo in the cGVHD setting. Current research interests include novel treatments for skin fibrosis and objective measurement tools to assess disease activity and response.
Dr. Cowen also participates in the NIH Undiagnosed Disease program and has been involved in the description of several novel syndromes in collaboration with other NIH investigators, including deficiency of the IL-1 receptor antagonist (DIRA), GATA2 deficiency, ADA2 deficiency, cutaneous skeletal hypophosphatemia syndrome, and SAVI syndrome. Most recently, Dr. Cowen identified onychopapilloma as a novel cutaneous finding in BAP1 tumor predisposition syndrome.
Biography
Edward W. Cowen, M.D., M.H.Sc., leads the NIH Dermatology Consultation Service, conducts independent and collaborative research, and oversees the continuing medication education-accredited Dermatology Grand Rounds, Branch Clinical Fellowship and resident education programs. He is an internationally recognized expert in cutaneous graft-versus-host disease. He is Director Emeritus of the American Board of Dermatology and serves on the Editorial Board of JAMA Dermatology and the Journal of the American Academy of Dermatology.
Selected Publications
- Rosenstein RK, Rose JJ, Brooks SR, Tsai WL, Gadina M, Pavletic SZ, Nagao K, Cowen EW. Identification of Fibroinflammatory and Fibrotic Transcriptomic Subsets of Human Cutaneous Sclerotic Chronic Graft-Versus-Host Disease. JID Innov. 2024;4(2):100246.
- Lebensohn A, Ghafoor A, Bloomquist L, Royer MC, Castelo-Soccio L, Karacki K, Hathaway O, Maglo T, Wagner C, Agra MG, Blakely AM, Schrump DS, Hassan R, Cowen EW. Multiple Onychopapillomas and BAP1 Tumor Predisposition Syndrome. JAMA Dermatol. 2024;160(8):838-845.
- Tan IJ, Ferrada MA, Ahmad S, Fike A, Quinn KA, Groarke EM, Beck DB, Allbritton J, Castelo-Soccio L, Young NS, Patel BA, Grayson PC, Cowen EW. Skin Manifestations of VEXAS Syndrome and Associated Genotypes. JAMA Dermatol. 2024;160(8):822-829.
- Baird K, Comis LE, Joe GO, Steinberg SM, Hakim FT, Rose JJ, Mitchell SA, Pavletic SZ, Figg WD, Yao L, Flanders KC, Takebe N, Sarantopoulos S, Booher S, Cowen EW. Imatinib mesylate for the treatment of steroid-refractory sclerotic-type cutaneous chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2015;21(6):1083-90.
- Martires KJ, Baird K, Steinberg SM, Grkovic L, Joe GO, Williams KM, Mitchell SA, Datiles M, Hakim FT, Pavletic SZ, Cowen EW. Sclerotic-type chronic GVHD of the skin: clinical risk factors, laboratory markers, and burden of disease. Blood. 2011;118(15):4250-7.
Related Scientific Focus Areas
This page was last updated on Saturday, September 21, 2024