Dennis D. Hickstein, M.D.
Experimental Transplantation and Immunology Branch
Building 10 - Hatfield CRC, Room 3-3142
Bethesda, MD 20892-1203
Molecular Oncology and Gene Transfer
The research in our laboratory involves two areas of investigations. The first area of study focuses on the correction of the disease phenotype in three genetic immunodeficiency diseases-leukocyte adhesion deficiency type 1, GATA2 deficiency, and DOCK8 deficiency-using two approaches: allogeneic hematopoietic stem cell transplantation and gene transfer into hematopoietic stem cells. These studies are designed to achieve long-term correction of hematopoietic stem cells. In the second area of study, we are developing zebrafish models of human blood diseases, particularly a zebrafish model of GATA2 deficiency.
Dr. Hickstein trained in hematology and hematopoietic stem cell transplantation at the University of Washington School of Medicine and the Fred Hutchinson Cancer Research center. He was recruited to the NCI in 2000 to transplant newly identifed primary immunodeficiency diseases.
Cuellar-Rodriguez J, Freeman AF, Grossman J, Su H, Parta M, Murdock H, Shah N, Bollard C, Kong HH, Moutsopoulos N, Stone K, Gea-Banacloche J, Holland SM, Hickstein DD. Matched related and unrelated donor hematopoietic stem cell transplantation for DOCK8 deficiency. Biol Blood Marrow Transplant. 2015;21(6):1037-45.
Grossman J, Cuellar-Rodriguez J, Gea-Banacloche J, Zerbe C, Calvo K, Hughes T, Hakim F, Cole K, Parta M, Freeman A, Holland SM, Hickstein DD. Nonmyeloablative allogeneic hematopoietic stem cell transplantation for GATA2 deficiency. Biol Blood Marrow Transplant. 2014;20(12):1940-8.
West RR, Hsu AP, Holland SM, Cuellar-Rodriguez J, Hickstein DD. Acquired ASXL1 mutations are common in patients with inherited GATA2 mutations and correlate with myeloid transformation. Haematologica. 2014;99(2):276-81.
Hsu AP, Johnson KD, Falcone EL, Sanalkumar R, Sanchez L, Hickstein DD, Cuellar-Rodriguez J, Lemieux JE, Zerbe CS, Bresnick EH, Holland SM. GATA2 haploinsufficiency caused by mutations in a conserved intronic element leads to MonoMAC syndrome. Blood. 2013;121(19):3830-7, S1-7.
Cuellar-Rodriguez J, Gea-Banacloche J, Freeman AF, Hsu AP, Zerbe CS, Calvo KR, Wilder J, Kurlander R, Olivier KN, Holland SM, Hickstein DD. Successful allogeneic hematopoietic stem cell transplantation for GATA2 deficiency. Blood. 2011;118(13):3715-20.
Related Scientific Focus Areas
Genetics and Genomics
This page was last updated on June 15th, 2017