David Lawrence Sacks, Ph.D.
Intracellular Parasite Biology Section
Building 4, Room B1-12
4 Memorial Drive
Bethesda, MD 20892
Research in the Intracellular Parasite Biology Section (IPBS) focuses on the immunology and cell biology of leishmanial infections and the biology of Leishmania parasites within their mammalian hosts and sand-fly vectors. The research may have relevance to diseases, such as tuberculosis, caused by other intracellular pathogens or to other vector-borne diseases, such as malaria.
The IPBS is composed of an interdisciplinary group of immunologists, cell biologists, entomologists, and computational biologists conducting basic and translational research aimed at the following:
- Understanding molecular interactions at the sand fly-Leishmania interface that control the development of transmissible infections, including the role of insect microbiota
- Exploiting a recently identified sexual cycle of Leishmania during their development in the sand fly vector to investigate sexual recombination as a key reproductive strategy to generate diversity, and to identify genes controlling important traits, such as virulence, tissue tropism, and drug resistance
- Understanding the role of myeloid subsets in the skin development of severe cutaneous pathology due to L. major
- Understanding the mechanisms underlying the immunologic defects in patients with visceral leishmaniasis in India, focusing on the role of IL-10 and its inhibition as an approach to therapy
- Identifying the important human infection reservoirs for transmission of visceral leishmaniasis in India
Dr. Sacks obtained his Ph.D. from Harvard University for studies on immune responses to chlamydial infections. Following a postdoctoral fellowship at the National Institute for Medical Research in London (Mill Hill) studying immune suppression in African trypanosomiasis, he joined the Laboratory of Parasitic Diseases in 1980. He became a senior investigator in 1986.
Lee SH, Charmoy M, Romano A, Paun A, Chaves MM, Cope FO, Ralph DA, Sacks DL. Mannose receptor high, M2 dermal macrophages mediate nonhealing <i>Leishmania major</i> infection in a Th1 immune environment. J Exp Med. 2018;215(1):357-375.
Inbar E, Shaik J, Iantorno SA, Romano A, Nzelu CO, Owens K, Sanders MJ, Dobson D, Cotton JA, Grigg ME, Beverley SM, Sacks D. Whole genome sequencing of experimental hybrids supports meiosis-like sexual recombination in Leishmania. PLoS Genet. 2019;15(5):e1008042.
Romano A, Inbar E, Debrabant A, Charmoy M, Lawyer P, Ribeiro-Gomes F, Barhoumi M, Grigg M, Shaik J, Dobson D, Beverley SM, Sacks DL. Cross-species genetic exchange between visceral and cutaneous strains of Leishmania in the sand fly vector. Proc Natl Acad Sci U S A. 2014;111(47):16808-13.
Akopyants NS, Kimblin N, Secundino N, Patrick R, Peters N, Lawyer P, Dobson DE, Beverley SM, Sacks DL. Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector. Science. 2009;324(5924):265-8.
Gautam S, Kumar R, Maurya R, Nylén S, Ansari N, Rai M, Sundar S, Sacks D. IL-10 neutralization promotes parasite clearance in splenic aspirate cells from patients with visceral leishmaniasis. J Infect Dis. 2011;204(7):1134-7.
Related Scientific Focus Areas
Microbiology and Infectious Diseases
Molecular Biology and Biochemistry
Genetics and Genomics
This page was last updated on July 24th, 2019