David Landsman, Ph.D.

Senior Investigator

Bioinformatics of Chromatin Structure Group

NLM/NCBI

Building 38A, Room 6N601
8600 Rockville Pike
Bethesda, MD 20894

301-435-5981

landsman@ncbi.nlm.nih.gov

Research Topics

Dr. Landsman's special interest is the merging of results obtained in computational biology analyses with those derived from experiments in biochemistry, molecular biology, cell biology, and genetics.

Biography

A biochemistry graduate of the University of Cape Town, South Africa, Dr. Landsman trained in molecular biology as a postdoctoral fellow in the National Cancer Institute under Dr. Michael Bustin at the NIH. He moved to the NCBI/NLM as a Senior Investigator, soon after its inception, where he initiated a computational biology and bioinformatics research program on the analysis of the genes and proteins involved in chromatin structure and in the regulation of gene expression in eukaryotes. He has concentrated on the analysis of both histone and non-histone chromosomal proteins as well as on the analysis of DNA sequences involved in gene regulatory events and chromatin structure. Dr. Landsman's group now analyzes the results of ChIP-seq experiments to achieve these goals.

Selected Publications

  1. Vera Alvarez R, Pongor LS, Mariño-Ramírez L, Landsman D. TPMCalculator: one-step software to quantify mRNA abundance of genomic features. Bioinformatics. 2019;35(11):1960-1962.

  2. Kale S, Goncearenco A, Markov Y, Landsman D, Panchenko AR. Molecular recognition of nucleosomes by binding partners. Curr Opin Struct Biol. 2019;56:164-170.

  3. Deng T, Zhu ZI, Zhang S, Leng F, Cherukuri S, Hansen L, Mariño-Ramírez L, Meshorer E, Landsman D, Bustin M. Correction for Deng et al., "HMGN1 Modulates Nucleosome Occupancy and DNase I Hypersensitivity at the CpG Island Promoters of Embryonic Stem Cells". Mol Cell Biol. 2018;38(12).

  4. Li S, Alvarez RV, Sharan R, Landsman D, Ovcharenko I. Quantifying deleterious effects of regulatory variants. Nucleic Acids Res. 2017;45(5):2307-2317.

  5. Shaytan AK, Armeev GA, Goncearenco A, Zhurkin VB, Landsman D, Panchenko AR. Coupling between Histone Conformations and DNA Geometry in Nucleosomes on a Microsecond Timescale: Atomistic Insights into Nucleosome Functions. J Mol Biol. 2016;428(1):221-237.


This page was last updated on August 28th, 2019