David Landsman, Ph.D.

Senior Investigator

Bioinformatics of Chromatin Structure Group


Building 38A, Room 6N601
8600 Rockville Pike
Bethesda, MD 20894



Research Topics

Dr. Landsman's special interest is the merging of results obtained in computational biology analyses with those derived from experiments in biochemistry, molecular biology, cell biology, and genetics.


A biochemistry graduate of the University of Cape Town, South Africa, Dr. Landsman trained in molecular biology as a postdoctoral fellow in the National Cancer Institute under Dr. Michael Bustin at the NIH. He moved to the NCBI/NLM as a Senior Investigator, soon after its inception, where he initiated a computational biology and bioinformatics research program on the analysis of the genes and proteins involved in chromatin structure and in the regulation of gene expression in eukaryotes. He has concentrated on the analysis of both histone and non-histone chromosomal proteins as well as on the analysis of DNA sequences involved in gene regulatory events and chromatin structure. Dr. Landsman's group now analyzes the results of ChIP-seq experiments to achieve these goals.

Selected Publications

  1. Deng T, Zhu ZI, Zhang S, Leng F, Cherukuri S, Hansen L, Mariño-Ramírez L, Meshorer E, Landsman D, Bustin M. HMGN1 modulates nucleosome occupancy and DNase I hypersensitivity at the CpG island promoters of embryonic stem cells. Mol Cell Biol. 2013;33(16):3377-89.

  2. Draizen EJ, Shaytan AK, Mariño-Ramírez L, Talbert PB, Landsman D, Panchenko AR. HistoneDB 2.0: a histone database with variants--an integrated resource to explore histones and their variants. Database (Oxford). 2016;2016.

  3. Hansen L, Kim NK, Mariño-Ramírez L, Landsman D. Analysis of biological features associated with meiotic recombination hot and cold spots in Saccharomyces cerevisiae. PLoS One. 2011;6(12):e29711.

  4. Mariño-Ramírez L, Spouge JL, Kanga GC, Landsman D. Statistical analysis of over-represented words in human promoter sequences. Nucleic Acids Res. 2004;32(3):949-58.

This page was last updated on July 17th, 2017