David S. Goldstein, M.D., Ph.D.
Clinical Neurocardiology Section
Building 10, Room 5N220
9000 Rockville Pike
10 Center Drive
Bethesda, MD 20892-1620
Dr. Goldstein's research interests are in autonomic medicine and catecholamine-related disorders. The Clinical Neurocardiology Section, which he founded and directs, carries out mainly patient-oriented research. The Section operates a renowned Clinical Neurochemistry Laboratory for assays of levels of catecholamines and their metabolites. Current research of the Section focuses on biomarkers, mechanisms, and potential treatment of catecholaminergic neurodegeneration in Parkinson's disease and related disorders.
An important new protocol in the Section NIH Protocol 17-N-0076, "Does N-Acetylcysteine Decrease Spontaneous Oxidation of Central Neural Dopamine in Parkinson’s Disease?" The purpose of the study is to find out if a drug called N-acetylcysteine (NAC) might be beneficial, by decreasing damage caused by oxidative stress in dopamine neurons in the brain. For more information, see the link to the NIH Clinical Center’s web page about the study at https://go.usa.gov/xXSsQ or see the YouTube video ad at https://www.youtube.com/watch?v=bbUcuxtVo6o.
Goldstein DS, Pekker MJ, Eisenhofer G, Sharabi Y. Computational modeling reveals multiple abnormalities of myocardial noradrenergic function in Lewy body diseases. JCI Insight. 2019;5.
Goldstein DS, Sullivan P, Holmes C, Miller GW, Alter S, Strong R, Mash DC, Kopin IJ, Sharabi Y. Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease. J Neurochem. 2013;126(5):591-603.
Goldstein DS, Holmes C, Sullivan P, Mash DC, Sidransky E, Stefani A, Kopin IJ, Sharabi Y. Deficient vesicular storage: A common theme in catecholaminergic neurodegeneration. Parkinsonism Relat Disord. 2015;21(9):1013-22.
Goldstein DS, Kopin IJ, Sharabi Y. Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders. Pharmacol Ther. 2014;144(3):268-82.
Goldstein DS. How does homeostasis happen? Integrative physiological, systems biological, and evolutionary perspectives. Am J Physiol Regul Integr Comp Physiol. 2019;316(4):R301-R317.
Related Scientific Focus Areas
Molecular Biology and Biochemistry
This page was last updated on September 1st, 2020