David H. Epstein, Ph.D.


Translational Addiction Medicine Branch, Real-world Assessment, Prediction, and Treatment Unit


Biomedical Research Center
251 Bayview Boulevard
Suite 200, Room 01B606
Baltimore, MD 21224



Research Topics

The RAPT Unit was established by Dr. Epstein in 2017 to bring the IRP’s treatment research into the age of predictive analytics and personalized medicine. Implicit in the name—“Real-world Assessment, Prediction, and Treatment”—is our intent to show that when addiction research moves forward, so do prevention and treatment. So our watchword, even if it sounds like a buzzword, is actionable:
  • We derive actionable information from our use of smartphones, GPS, and biosensors in everyday assessment of people’s moods, exposure to built and social environments, and drug use. That information can help us deliver mobile treatments, electronically, when and where they’re needed.
  • We formulate actionable ideas from neuroscience and laboratory-based behavioral sciences, collaborating closely with colleagues at the IRP and worldwide to translate their discoveries into treatments.
Our aim is to maintain a portfolio of studies that, taken together, address the whole continuum of causes of addiction, from the psychosocial to the neurobiological, and to use our wide in-house expertise to match the tool to the task for different kinds of patients.

Selected Publications

  1. Smith KE, Feldman JD, Dunn KE, McCurdy CR, Grundmann O, Garcia-Romeu A, Panlilio LV, Rogers JM, Sharma A, Pont-Fernandez S, Kheyfets M, Epstein DH. Novel methods for the remote investigation of emerging substances: Application to kratom. Exp Clin Psychopharmacol. 2023.
  2. Stull SW, Bertz JW, Panlilio LV, Kowalczyk WJ, Phillips KA, Moran LM, Lin JL, Vahabzadeh M, Finan PH, Preston KL, Epstein DH. I feel good? Anhedonia might not mean "without pleasure" for people treated for opioid use disorder. J Abnorm Psychol. 2021;130(5):537-549.
  3. Panlilio LV, Lee A, Smith KE, Epstein DH. Were self-described introverts "immune" to increased drug use and entrapment during the pandemic? Drug Alcohol Depend Rep. 2022;2:100024.
  4. Burgess-Hull AJ, Panlilio LV, Preston KL, Epstein DH. Trajectories of craving during medication-assisted treatment for opioid-use disorder: Subtyping for early identification of higher risk. Drug Alcohol Depend. 2022;233:109362.

Related Scientific Focus Areas

This page was last updated on Friday, November 2, 2018