Darlene Dixon, D.V.M., Ph.D.

Senior Investigator

National Toxicology Program/Molecular Pathogenesis Group

NIEHS

B341 Rall Building
111 T W Alexander Dr
Research Triangle Park, NC 27709

984-287-3848

dixon@niehs.nih.gov

Research Topics

Dixon’s group focuses on defining the pathogenesis/carcinogenesis of tumors affecting the reproductive tract of rodents and humans and assessing the role of environmental and endogenous hormonal factors in the growth of these tumors.

The group has used cell lines, 3D cultures, archival mouse tissue, and human clinical samples to study the influence of membrane-associated estrogen receptors and growth factors/receptors and their signaling pathways on uterine leiomyoma (fibroid) growth. Group members use leiomyoma and patient-matched myometrial samples, clinical tissues taken from cycle-staged, premenopausal women participating in the NIEHS George Washington University Fibroid Study. The rodent tissue samples are either from in-house studies or National Toxicology Program archives.

Dixon and her group seek to understand the basic molecular mechanisms of disease, which may lead to therapeutic interventions that generate alternative non-invasive treatments for clinical fibroids and other diseases affecting the female reproductive tract.

Biography

Dixon earned her Doctor of Veterinary Medicine (D.V.M.) degree in 1982 at Tuskegee University School of Veterinary Medicine and her Ph.D. in 1985 at Michigan State University. She also completed a postdoctoral fellowship at The Rockefeller University, Laboratory Animal Research Center. Dixon received her board certification from the American College of Veterinary Pathologists (ACVP) in 1987 and joined NIEHS the same year.

Selected Publications

  1. Liu J, Yu L, Castro L, Yan Y, Sifre MI, Bortner CD, Dixon D. A nongenomic mechanism for "metalloestrogenic" effects of cadmium in human uterine leiomyoma cells through G protein-coupled estrogen receptor. Arch Toxicol. 2019.

  2. Yu L, Das P, Vall AJ, Yan Y, Gao X, Sifre MI, Bortner CD, Castro L, Kissling GE, Moore AB, Dixon D. Bisphenol A induces human uterine leiomyoma cell proliferation through membrane-associated ERα36 via nongenomic signaling pathways. Mol Cell Endocrinol. 2019;484:59-68.

  3. Flake GP, Moore AB, Sutton D, Flagler N, Clayton N, Kissling GE, Hall BW, Horton J, Walmer D, Robboy SJ, Dixon D. The Life Cycle of the Uterine Fibroid Myocyte. Curr Obstet Gynecol Rep. 2018;7(2):97-105.

  4. Yan Y, Yu L, Castro L, Dixon D. ERα36, a variant of estrogen receptor α, is predominantly localized in mitochondria of human uterine smooth muscle and leiomyoma cells. PLoS One. 2017;12(10):e0186078.

  5. Yu L, Ham K, Gao X, Castro L, Yan Y, Kissling GE, Tucker CJ, Flagler N, Dong R, Archer TK, Dixon D. Epigenetic regulation of transcription factor promoter regions by low-dose genistein through mitogen-activated protein kinase and mitogen-and-stress activated kinase 1 nongenomic signaling. Cell Commun Signal. 2016;14(1):18.


This page was last updated on September 4th, 2019