Cari Meinhold Kitahara, Ph.D.

Investigator

Radiation Epidemiology Branch

NCI/DCEG

9609 Medical Center Drive
Room SG/7E536
Rockville, MD 20850

240-276-7406

meinholdc@mail.nih.gov

Research Topics

Occupational Radiation Exposure and Cancer

Everyone receives some degree of exposure to ionizing radiation—a known carcinogen—from both natural and man-made sources. Epidemiologists face many challenges when seeking to quantify the relationship between low levels of radiation and health risks in the general population. Occupational groups, such as radiologic technologists, are routinely monitored for radiation exposure as part of worker-safety measures, and thus provide a unique setting for studying associations between radiation and cancer. Dr. Kitahara is particularly interested in cancer risks associated with occupational exposure to low-dose radiation from emerging medical practices and procedures. Much of her current work focuses on nuclear medicine procedures (i.e., those involving radionuclides). Some of these procedures, including those that emit higher gamma radiation energy (e.g., positron emission tomography [PET]), are being performed with increasing frequency over time, potentially yielding greater cumulative exposure to the technologists who perform them. Findings from these studies can inform current radiation protection practices for medical radiation workers and, more broadly, improve our understanding of the impact of low-dose radiation exposure on the risk of cancer in the general population.

Etiology of Radiosensitive Cancers

A broader understanding of the etiology of radiation-associated cancers, including potential effect modifiers, is important for the study of radiation and cancer. Exposure to ionizing radiation during childhood is one of the few established risk factors for thyroid cancer and glioma; the thyroid and brain are two of the most radiosensitive organs. The relatively low incidence of these two malignancies makes them difficult to study. Of the few epidemiologic studies of non-ionizing radiation in relation to thyroid cancer and glioma, most are based on small numbers of incident cases or are case-control in design. Dr. Kitahara’s research utilizes data from large prospective studies to address long-standing and new hypotheses regarding the influence of certain exposures (e.g., obesity, diet, smoking, and hormone use) across the life course on the risk of these two malignancies. Some examples of this work include a large pooled analysis of five prospective NCI studies on lifestyle-related factors and thyroid cancer risk. She has expanded this effort to include 22 prospective studies from the NCI Cohort Consortium. These studies, based in  North America, Asia, and Europe, allow her to evaluate associations for anthropometric factors and other potential thyroid cancer risk factors by histological subtype. Using data from the GliomaScan consortium, Dr. Kitahara and colleagues evaluated the association for height and history of diabetes, as well as genetic polymorphisms, in relation to glioma risk. Dr. Kitahara has also worked with colleagues at the Institute of Preventive Medicine in Copenhagen, Denmark, to evaluate measured height and weight in childhood in relation to risk of thyroid cancer and glioma in adulthood.

Biography

Dr. Kitahara earned her Ph.D. in cancer epidemiology from the Johns Hopkins Bloomberg School of Public Health. She joined the Radiation Epidemiology Branch in 2008 as a predoctoral fellow and became a research fellow in 2011. In 2015, she was appointed to the position of tenure-track investigator. Dr. Kitahara’s research focuses on low-dose radiation exposure and cancer risks in medical workers and the etiology of radiosensitive cancers, particularly thyroid cancer and glioma. She has received numerous awards for her work, including the DCEG Fellows Award for Research Excellence and the Outstanding Achievement in Science Seminar Series Award. Dr. Kitahara has a B.S. degree from the University of Michigan in biology and anthropology (2005) and an M.H.S. degree from the Johns Hopkins Bloomberg School of Public Health (2008).

Selected Publications

  1. Kitahara CM, Linet MS, Rajaraman P, Ntowe E, Berrington de González A. A New Era of Low-Dose Radiation Epidemiology. Curr Environ Health Rep. 2015;2(3):236-49.

  2. Kitahara CM, Flint AJ, Berrington de Gonzalez A, Bernstein L, Brotzman M, MacInnis RJ, Moore SC, Robien K, Rosenberg PS, Singh PN, Weiderpass E, Adami HO, Anton-Culver H, Ballard-Barbash R, Buring JE, Freedman DM, Fraser GE, Beane Freeman LE, Gapstur SM, Gaziano JM, Giles GG, Håkansson N, Hoppin JA, Hu FB, Koenig K, Linet MS, Park Y, Patel AV, Purdue MP, Schairer C, Sesso HD, Visvanathan K, White E, Wolk A, Zeleniuch-Jacquotte A, Hartge P. Association between class III obesity (BMI of 40-59 kg/m2) and mortality: a pooled analysis of 20 prospective studies. PLoS Med. 2014;11(7):e1001673.

  3. Kitahara CM, Gamborg M, Rajaraman P, Sørensen TI, Baker JL. A prospective study of height and body mass index in childhood, birth weight, and risk of adult glioma over 40 years of follow-up. Am J Epidemiol. 2014;180(8):821-9.

  4. Kitahara CM, McCullough ML, Franceschi S, Rinaldi S, Wolk A, Neta G, Olov Adami H, Anderson K, Andreotti G, Beane Freeman LE, Bernstein L, Buring JE, Clavel-Chapelon F, De Roo LA, Gao YT, Gaziano JM, Giles GG, Håkansson N, Horn-Ross PL, Kirsh VA, Linet MS, MacInnis RJ, Orsini N, Park Y, Patel AV, Purdue MP, Riboli E, Robien K, Rohan T, Sandler DP, Schairer C, Schneider AB, Sesso HD, Shu XO, Singh PN, van den Brandt PA, Ward E, Weiderpass E, White E, Xiang YB, Zeleniuch-Jacquotte A, Zheng W, Hartge P, de González AB. Anthropometric Factors and Thyroid Cancer Risk by Histological Subtype: Pooled Analysis of 22 Prospective Studies. Thyroid. 2016;26(2):306-18.

  5. Kitahara CM, Linet MS, Drozdovitch V, Alexander BH, Preston DL, Simon SL, Freedman DM, Brill AB, Miller JS, Little MP, Rajaraman P, Doody MM. Cancer and circulatory disease risks in US radiologic technologists associated with performing procedures involving radionuclides. Occup Environ Med. 2015;72(11):770-6.

Related Scientific Focus Areas


This page was last updated on March 22nd, 2016