Bryan Joseph Traynor, M.D., Ph.D., M.M.Sc, M.R.C.P.I

Senior Investigator

Laboratory of Neurogenetics

NIA

Building 35, Room 1A1000
35 Convent Drive
Bethesda, MD 20814

301-451-7606

traynorb@mail.nih.gov

Research Topics

Dr. Traynor is best known for his work aimed at understanding the genetic etiology of ALS. In 2011, he led the international consortium that identified a pathogenic hexanucleotide repeat expansion in the C9ORF72 gene as the underlying mutation in a large proportion of ALS and frontotemporal dementia (Neuron 2011). His team also identified the same mutation in ~1% of patients clinically diagnosed with Alzheimer’s disease (NEJM 2012).

Other notable achievements of his laboratory include the first genome-wide association study of ALS (Lancet Neuro 2007); identification of the chromosome 9p21 association signal for ALS in the Finnish founder population (Lancet Neuro 2010); and discovery of mutations in the VCP and MATR3 genes as a cause of familial ALS (Neuron 2010, Nature Neuroscience 2014).

Dr. Traynor has over 160 publications in various professional journals including New England Journal of Medicine, Nature, Nature Genetics, Nature Neuroscience, Neuron, Annals of Neurology, Lancet Neurology, and Proceedings of the National Academy of Sciences (PNAS). He is a member of various grant review committees including the Scientific Review Committee of The ALS Association, the Integration Panel for the Congressionally Directed Department of Defense Alzheimer’s Disease Research Programs, and the Genetics of Health and Disease NIH Study Section. He also chairs the Integration Panel for the Congressionally Directed Department of Defense ALS Research, and is an editorial board member for the Journal of Neurology, Neurosurgery, and Psychiatry and Neurobiology of Aging.

Dr. Traynor is the recipient of the NIA Director’s Award (2011), the NIH Director’s Award (2012), the John W. Griffin Innovator Award (2012), the Derek Denny Brown Neurological Scholar Award (2012), the Sheila Essey Award for ALS Research (2013) and the Diamond Award (2013).

Biography

Dr. Bryan J. Traynor is a Neurologist and a Senior Investigator at the National Institute on Aging. He has been the Chief of the Neuromuscular Diseases Research Section at the Laboratory of Neurogenetics since 2009. His laboratory is focused on unraveling the genetic etiology of amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease) and other neuromuscular disorders.

Dr. Traynor received his medical degree (MB, BCh, BAO) in 1993, his Medical Doctorate (MD) in 2000, and his Doctor of Philosophy (PhD) in 2012, all from his Alma mater University College Dublin. He also received a Masters in Medical Science (MMSc) from Harvard University and Massachusetts Institute of Technology in 2004. He has been a Member of the Royal College of Physicians of Ireland (MRCPI) since 1996 and an elected Fellow of the American Neurological Association since 2012.

Dr. Traynor’s academic history includes: Internal Medicine Residency at St. Vincent’s University Hospital, Dublin; Neurology Residency and Fellowship at the National Neuroscience Center of Ireland, Beaumont Hospital, Dublin. He moved to Boston in 1999, where he was a Neurology Resident, an ALS/Neuromuscular Fellow, and an Instructor and Staff Neurologist at Harvard Medical School and Massachusetts General Hospital. He then moved to National Institutes of Health, Bethesda, in 2005, where he has been a Clinical Associate, Assistant Clinical Investigator, Investigator, and is currently a tenured Senior Investigator from 2014 to present. He has also been an adjunct faculty member of the Neurology Department at Johns Hopkins, Baltimore since 2006.

Selected Publications

  1. Renton AE, Majounie E, Waite A, Simón-Sánchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H, van Swieten JC, Myllykangas L, Kalimo H, Paetau A, Abramzon Y, Remes AM, Kaganovich A, Scholz SW, Duckworth J, Ding J, Harmer DW, Hernandez DG, Johnson JO, Mok K, Ryten M, Trabzuni D, Guerreiro RJ, Orrell RW, Neal J, Murray A, Pearson J, Jansen IE, Sondervan D, Seelaar H, Blake D, Young K, Halliwell N, Callister JB, Toulson G, Richardson A, Gerhard A, Snowden J, Mann D, Neary D, Nalls MA, Peuralinna T, Jansson L, Isoviita VM, Kaivorinne AL, Hölttä-Vuori M, Ikonen E, Sulkava R, Benatar M, Wuu J, Chiò A, Restagno G, Borghero G, Sabatelli M, ITALSGEN Consortium., Heckerman D, Rogaeva E, Zinman L, Rothstein JD, Sendtner M, Drepper C, Eichler EE, Alkan C, Abdullaev Z, Pack SD, Dutra A, Pak E, Hardy J, Singleton A, Williams NM, Heutink P, Pickering-Brown S, Morris HR, Tienari PJ, Traynor BJ. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron. 2011;72(2):257-68.

  2. Johnson JO, Mandrioli J, Benatar M, Abramzon Y, Van Deerlin VM, Trojanowski JQ, Gibbs JR, Brunetti M, Gronka S, Wuu J, Ding J, McCluskey L, Martinez-Lage M, Falcone D, Hernandez DG, Arepalli S, Chong S, Schymick JC, Rothstein J, Landi F, Wang YD, Calvo A, Mora G, Sabatelli M, Monsurrò MR, Battistini S, Salvi F, Spataro R, Sola P, Borghero G, ITALSGEN Consortium., Galassi G, Scholz SW, Taylor JP, Restagno G, Chiò A, Traynor BJ. Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron. 2010;68(5):857-64.

  3. Johnson JO, Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y, Marangi G, Winborn BJ, Gibbs JR, Nalls MA, Morgan S, Shoai M, Hardy J, Pittman A, Orrell RW, Malaspina A, Sidle KC, Fratta P, Harms MB, Baloh RH, Pestronk A, Weihl CC, Rogaeva E, Zinman L, Drory VE, Borghero G, Mora G, Calvo A, Rothstein JD, ITALSGEN., Drepper C, Sendtner M, Singleton AB, Taylor JP, Cookson MR, Restagno G, Sabatelli M, Bowser R, Chiò A, Traynor BJ. Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nat Neurosci. 2014;17(5):664-666.

  4. Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, Van der Spek RA, Pliner HA, Shankaracharya, Smith BN, Marangi G, Topp SD, Abramzon Y, Gkazi AS, Eicher JD, Kenna A, ITALSGEN Consortium., Mora G, Calvo A, Mazzini L, Riva N, Mandrioli J, Caponnetto C, Battistini S, Volanti P, La Bella V, Conforti FL, Borghero G, Messina S, Simone IL, Trojsi F, Salvi F, Logullo FO, D'Alfonso S, Corrado L, Capasso M, Ferrucci L, Genomic Translation for ALS Care (GTAC) Consortium., Moreno CAM, Kamalakaran S, Goldstein DB, ALS Sequencing Consortium., Gitler AD, Harris T, Myers RM, NYGC ALS Consortium., Phatnani H, Musunuri RL, Evani US, Abhyankar A, Zody MC, Answer ALS Foundation., Kaye J, Finkbeiner S, Wyman SK, LeNail A, Lima L, Fraenkel E, Svendsen CN, Thompson LM, Van Eyk JE, Berry JD, Miller TM, Kolb SJ, Cudkowicz M, Baxi E, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium., Benatar M, Taylor JP, Rampersaud E, Wu G, Wuu J, SLAGEN Consortium., Lauria G, Verde F, Fogh I, Tiloca C, Comi GP, Sorarù G, Cereda C, French ALS Consortium., Corcia P, Laaksovirta H, Myllykangas L, Jansson L, Valori M, Ealing J, Hamdalla H, Rollinson S, Pickering-Brown S, Orrell RW, Sidle KC, Malaspina A, Hardy J, Singleton AB, Johnson JO, Arepalli S, Sapp PC, McKenna-Yasek D, Polak M, Asress S, Al-Sarraj S, King A, Troakes C, Vance C, de Belleroche J, Baas F, Ten Asbroek ALMA, Muñoz-Blanco JL, Hernandez DG, Ding J, Gibbs JR, Scholz SW, Floeter MK, Campbell RH, Landi F, Bowser R, Pulst SM, Ravits JM, MacGowan DJL, Kirby J, Pioro EP, Pamphlett R, Broach J, Gerhard G, Dunckley TL, Brady CB, Kowall NW, Troncoso JC, Le Ber I, Mouzat K, Lumbroso S, Heiman-Patterson TD, Kamel F, Van Den Bosch L, Baloh RH, Strom TM, Meitinger T, Shatunov A, Van Eijk KR, de Carvalho M, Kooyman M, Middelkoop B, Moisse M, McLaughlin RL, Van Es MA, Weber M, Boylan KB, Van Blitterswijk M, Rademakers R, Morrison KE, Basak AN, Mora JS, Drory VE, Shaw PJ, Turner MR, Talbot K, Hardiman O, Williams KL, Fifita JA, Nicholson GA, Blair IP, Rouleau GA, Esteban-Pérez J, García-Redondo A, Al-Chalabi A, Project MinE ALS Sequencing Consortium., Rogaeva E, Zinman L, Ostrow LW, Maragakis NJ, Rothstein JD, Simmons Z, Cooper-Knock J, Brice A, Goutman SA, Feldman EL, Gibson SB, Taroni F, Ratti A, Gellera C, Van Damme P, Robberecht W, Fratta P, Sabatelli M, Lunetta C, Ludolph AC, Andersen PM, Weishaupt JH, Camu W, Trojanowski JQ, Van Deerlin VM, Brown RH Jr, van den Berg LH, Veldink JH, Harms MB, Glass JD, Stone DJ, Tienari P, Silani V, Chiò A, Shaw CE, Traynor BJ, Landers JE. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. Neuron. 2018;97(6):1268-1283.e6.

  5. Laaksovirta H, Peuralinna T, Schymick JC, Scholz SW, Lai SL, Myllykangas L, Sulkava R, Jansson L, Hernandez DG, Gibbs JR, Nalls MA, Heckerman D, Tienari PJ, Traynor BJ. Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study. Lancet Neurol. 2010;9(10):978-85.


This page was last updated on August 24th, 2018