Brandon Harvey, Ph.D.

Investigator

Integrative Neuroscience Branch, Molecular Mechanisms of Cellular Stress and Inflammation

NIDA

View site

Biomedical Research Center
251 Bayview Boulevard
Suite 200, Room 06A729
Baltimore, MD 21224

443-740-2590

bharvey@mail.nih.gov

Research Topics

Dr. Harvey received his Ph.D. in Neurobiology and Anatomy from the University of Rochester where he began his interest in gene delivery and gene therapy for the central nervous system. He joined NIDA in 2002 where he brought methods for viral vector production to the Neural Protection and Regeneration Section led by Dr. Yun Wang. Dr. Harvey’s experience with molecular biology and viral vectors coupled with his background in the models of neurodegeneration and neurotoxicity contribute to his directorship of the Optogenetics and Transgenic Technology Core where he develops genetic tools for monitoring and manipulating the activity of neurons and glia in the rodent central nervous system. Dr. Harvey also has an ongoing research project as part of the Cellular Protection and Repair (CPR) laboratory examining the protein Mesencephalic Astrocyte Derived Neurotrophic Factor (MANF) and its associated functions in the neuroprotection, ER stress, unfolded protein response (UPR) and the KDEL retrieval pathway.

Selected Publications

  1. Trychta KA, Bäck S, Henderson MJ, Harvey BK. KDEL Receptors Are Differentially Regulated to Maintain the ER Proteome under Calcium Deficiency. Cell Rep. 2018;25(7):1829-1840.e6.

  2. Henderson MJ, Trychta KA, Yang SM, Bäck S, Yasgar A, Wires ES, Danchik C, Yan X, Yano H, Shi L, Wu KJ, Wang AQ, Tao D, Zahoránszky-Kőhalmi G, Hu X, Xu X, Maloney D, Zakharov AV, Rai G, Urano F, Airavaara M, Gavrilova O, Jadhav A, Wang Y, Simeonov A, Harvey BK. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell Rep. 2021;35(4):109040.

  3. Bäck S, Necarsulmer J, Whitaker LR, Coke LM, Koivula P, Heathward EJ, Fortuno LV, Zhang Y, Yeh CG, Baldwin HA, Spencer MD, Mejias-Aponte CA, Pickel J, Hoffman AF, Spivak CE, Lupica CR, Underhill SM, Amara SG, Domanskyi A, Anttila JE, Airavaara M, Hope BT, Hamra FK, Richie CT, Harvey BK. Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats. Neuron. 2019;102(1):105-119.e8.

  4. Wires ES, Trychta KA, Bäck S, Sulima A, Rice KC, Harvey BK. High fat diet disrupts endoplasmic reticulum calcium homeostasis in the rat liver. J Hepatol. 2017;67(5):1009-1017.

  5. Trychta KA, Heathward EJ, Sulima A, Bäck S, Farokhnia M, Richie CT, Leggio L, Rice KC, Harvey BK. Extracellular esterase activity as an indicator of endoplasmic reticulum calcium depletion. Biomarkers. 2018;23(8):756-765.

Related Scientific Focus Areas

This page was last updated on November 2nd, 2018