Augustin Luna, Ph.D.

Stadtman Investigator

Computational Biology Branch

NLM

Building 38A, Room 6N603
8600 Rockville Pike
Bethesda, MD 20894

augustin@nih.gov

Research Topics

Dr. Augustin Luna is a Stadtman Tenure-track Investigator and Distinguished Scholar with a primary appointment at the National Library of Medicine (NLM) and a secondary appointment at the National Cancer Institute (NCI). Research in the laboratory of Dr. Augustin Luna seeks to understand disease biology through the development of mechanistic and statistical computational models that involve various aspects of gene regulation, genomic alterations, proteomics, and metabolism both through pan-cancer analysis and analysis of specific cancers, including rare cancers. The goal of the work is to address key questions in our understanding of network properties of human disease and to utilize this knowledge to improve treatment options and clinical decision-making through interpretable methodologies.

In support of FAIR (Findable, Accessible, Interoperable, and Reusable) principles of scientific research, Augustin has been a long-term member of communities working on standardized representations of biological data (e.g., the Biological Pathway Exchange format and the Systems Biology Graphical Notation). These data representations are key components of several molecular interaction databases and a basis for network-based methods and software tools that Dr. Luna has worked with colleagues to build in order to address key questions in our understanding of network properties of human disease.

Biography

Dr. Luna has a Ph.D. in Bioinformatics from Boston University as part of a joint program with the National Cancer Institute. He earned a B.Sc. in Biomedical Engineering from the Georgia Institute of Technology and was previously a Research Associate at Harvard Medical School with an affiliation at the Broad Institute of MIT/Harvard. Before this, Dr. Luna was a post-doctoral researcher at the Memorial Sloan-Kettering Cancer Center in New York City and the Dana-Farber Cancer Institute in Boston.

Dr. Luna has received The Fund for Innovation in Cancer Informatics (ICI) Discovery Grant, BroadIgnite Award, Ruth L. Kirschstein National Research Service Award (NRSA), and, earlier, a Dissertation Fellowship from the Ford Foundation. Dr. Luna is a regular presenter of both national and international conferences.

Selected Publications

  1. Tlemsani C, Heske CM, Elloumi F, Pongor L, Khandagale P, Varma S, Luna A, Meltzer PS, Khan J, Reinhold WC, Pommier Y. Sarcoma_CellminerCDB: A tool to interrogate the genomic and functional characteristics of a comprehensive collection of sarcoma cell lines. iScience. 2024;27(6):109781.
  2. Peidli S, Green TD, Shen C, Gross T, Min J, Garda S, Yuan B, Schumacher LJ, Taylor-King JP, Marks DS, Luna A, Blüthgen N, Sander C. scPerturb: harmonized single-cell perturbation data. Nat Methods. 2024;21(3):531-540.
  3. Niarakis A, Ostaszewski M, Mazein A, Kuperstein I, Kutmon M, Gillespie ME, Funahashi A, Acencio ML, Hemedan A, Aichem M, Klein K, Czauderna T, Burtscher F, Yamada TG, Hiki Y, Hiroi NF, Hu F, Pham N, Ehrhart F, Willighagen EL, Valdeolivas A, Dugourd A, Messina F, Esteban-Medina M, Peña-Chilet M, Rian K, Soliman S, Aghamiri SS, Puniya BL, Naldi A, Helikar T, Singh V, Fernández MF, Bermudez V, Tsirvouli E, Montagud A, Noël V, Ponce-de-Leon M, Maier D, Bauch A, Gyori BM, Bachman JA, Luna A, Piñero J, Furlong LI, Balaur I, Rougny A, Jarosz Y, Overall RW, Phair R, Perfetto L, Matthews L, Rex DAB, Orlic-Milacic M, Gomez LCM, De Meulder B, Ravel JM, Jassal B, Satagopam V, Wu G, Golebiewski M, Gawron P, Calzone L, Beckmann JS, Evelo CT, D'Eustachio P, Schreiber F, Saez-Rodriguez J, Dopazo J, Kuiper M, Valencia A, Wolkenhauer O, Kitano H, Barillot E, Auffray C, Balling R, Schneider R, COVID-19 Disease Map Community. Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches. Front Immunol. 2023;14:1282859.

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This page was last updated on Monday, June 30, 2025