The focus of Dr. Biragyn's research is to understand the “immunological paradox of aging”; that is, why cancer incidence is enhanced but cancers often grow more slowly in older people, and why autoimmunity is more prevalent in the elderly but older people have poor vaccine responses. He hypothesizes that this may be a reflection of age-associated impairment of the regulatory immune cells. He studies cancer-mediated immunoregulation to gain insight on the role of regulatory immune cells and to develop potent immunotherapeutics tailored for elderly.
Dr. Arya Biragyn received his Ph.D. from the Institute of Molecular Biology at Engelgardt, Academy of Sciences of Russia, Moscow, in 1991. He obtained postdoctoral training from the University of Illinois at Urbana from 1991-1992 and the National Cancer Institute from 1992-1996. From 1996-2000 he was a scientist at the Science International Applications Corp. in Frederick, MD, where he worked on the development of new generation therapeutic vaccines for B cell lymphomas. In 2000 he moved to the Vaccine Biology Section, National Cancer Institute as a Staff Scientist, where he continued his cancer vaccine studies. From 2003 to 2011, he was a tenure-track investigator at the Laboratory of Immunology and, since 2011, he is a tenured senior investigator at the Laboratory of Molecular Biology and Immunology, National Institute on Aging.
- Bodogai M, O'Connell J, Kim K, Kim Y, Moritoh K, Chen C, Gusev F, Vaughan K, Shulzhenko N, Mattison JA, Lee-Chang C, Chen W, Carlson O, Becker KG, Gurung M, Morgun A, White J, Meade T, Perdue K, Mack M, Ferrucci L, Trinchieri G, de Cabo R, Rogaev E, Egan J, Wu J, Biragyn A. Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells. Sci Transl Med. 2018;10(467).
- Lee-Chang C, Bodogai M, Moritoh K, Olkhanud PB, Chan AC, Croft M, Mattison JA, Holst PJ, Gress RE, Ferrucci L, Hakim F, Biragyn A. Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity. Blood. 2014;124(9):1450-9.
- Ragonnaud E, Moritoh K, Bodogai M, Gusev F, Garaud S, Chen C, Wang X, Baljinnyam T, Becker KG, Maul RW, Willard-Gallo K, Rogaev E, Biragyn A. Tumor-Derived Thymic Stromal Lymphopoietin Expands Bone Marrow B-cell Precursors in Circulation to Support Metastasis. Cancer Res. 2019;79(22):5826-5838.
- Olkhanud PB, Damdinsuren B, Bodogai M, Gress RE, Sen R, Wejksza K, Malchinkhuu E, Wersto RP, Biragyn A. Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4⁺ T cells to T-regulatory cells. Cancer Res. 2011;71(10):3505-15.
- Biragyn A, Ruffini PA, Leifer CA, Klyushnenkova E, Shakhov A, Chertov O, Shirakawa AK, Farber JM, Segal DM, Oppenheim JJ, Kwak LW. Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science. 2002;298(5595):1025-9.
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Microbiology and Infectious Diseases
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This page was last updated on Monday, August 3, 2020