Armin Raznahan, M.D., Ph.D.

Lasker Clinical Research Scholar

Developmental Neurogenomics Unit, Human Genetics Branch

NIMH

Magnuson Clinical Center (Building 10), Room 4D18
10 Center Drive
Bethesda, MD 20814

301-435-7927

raznahana@mail.nih.gov

Research Topics

The Developmental Neurogenomics Unit (DNU) is dedicated to better understanding the biology of childhood-onset neuropsychiatric disorders in ways that might ultimately help to improve disease prediction, detection and treatment. Together with our collaborators, we work towards this goal in two mutually-informative ways.

First, we use large-scale longitudinal neuroimaging datasets to study the architecture of brain development in healthy volunteers. By modeling how neuroimaging measures of the human brain vary with age, sex and behavior in health, we hope to advance basic developmental neuroscience while also providing a data-driven way of selecting neuroimaging measures that should be prioritized for study in atypically developing groups.

Second, we use a “genetics-first” strategy to study the relationship between atypical brain development and neuropsychiatric symptoms. This effort involves gathering “deep-phenotypic” data (spanning measures of gene expression, brain structure/function, psychophysiology, cognition and behavior) in diverse genetic disorders which all increase risk for neuropsychiatric impairment. Guided by knowledge of typical development, we harness these clinical data to empirically dissect the diverse biological pathways that can contribute to the emergence of neuropsychiatric syndromes.

Cross-cutting themes of special interest within our Unit include sex-differences, allometry, and structure-function relationships within the central nervous system.

Biography

Armin Raznahan, MD, PhD, is a Lasker Clinical Research Scholar and Chief of the Developmental Neurogenomics Unit. His research combines neuroimaging, genomic and bioinformatic techniques to better understand the architecture of human brain development in health, and in neurogenetic disorders that increase risk for psychiatric symptoms. Clinically, Dr. Raznahan works as a Child Psychiatrist within the NIH Clinical Center Psychiatry Consultation Liaison Service. He has a degree in Medicine and a PhD in Biological Psychiatry from King¹s College University London, UK. He has completed residencies in pediatrics and psychiatry, and a specialist fellowship in child and adolescent psychiatry at the Maudsley Hospital, London, UK.

Selected Publications

  1. Mankiw C, Park MTM, Reardon PK, Fish AM, Clasen LS, Greenstein D, Giedd JN, Blumenthal JD, Lerch JP, Chakravarty MM, Raznahan A. Allometric Analysis Detects Brain Size-Independent Effects of Sex and Sex Chromosome Complement on Human Cerebellar Organization. J Neurosci. 2017;37(21):5221-5231.

  2. Raznahan A, Shaw P, Lalonde F, Stockman M, Wallace GL, Greenstein D, Clasen L, Gogtay N, Giedd JN. How does your cortex grow? J Neurosci. 2011;31(19):7174-7.

  3. Raznahan A, Lerch JP, Lee N, Greenstein D, Wallace GL, Stockman M, Clasen L, Shaw PW, Giedd JN. Patterns of coordinated anatomical change in human cortical development: a longitudinal neuroimaging study of maturational coupling. Neuron. 2011;72(5):873-84.

  4. Raznahan A, Lue Y, Probst F, Greenstein D, Giedd J, Wang C, Lerch J, Swerdloff R. Triangulating the sexually dimorphic brain through high-resolution neuroimaging of murine sex chromosome aneuploidies. Brain Struct Funct. 2015;220(6):3581-93.

  5. Raznahan A, Lee NR, Greenstein D, Wallace GL, Blumenthal JD, Clasen LS, Giedd JN. Globally Divergent but Locally Convergent X- and Y-Chromosome Influences on Cortical Development. Cereb Cortex. 2016;26(1):70-9.


This page was last updated on October 3rd, 2017