Ariel Levine, M.D., Ph.D.
Spinal Circuits and Plasticity Unit
Building 35, Room 2B-1002
35 Convent Drive
Bethesda, MD 20892
We seek to understand how the molecules, cells, and circuits of the spinal cord mediate normal behavior, and how they change and adapt to allow learning. Far from being a passive relay between the brain and body, the spinal cord constantly integrates cues from the cortex, the brainstem, and sensory neurons, as well as other sources, and it ultimately transforms these cues into behavior. Further, the circuits of the spinal cord are dynamic. They learn in response to changes in incoming information. This happens during development, maturation, and in the adult animal.
We recently discovered a population of spinal neurons that directly receive cortical and sensory inputs and in turn, directly target the spinal motorneurons. Stimulating small clusters of neurons within this molecularly-defined population is sufficient to drive coordinated activation of multiple motor groups. This simple response may represent a “motor synergy” – modular motor programs that are hypothesized to be the core building blocks of our most common movements.
Now, we want to know: How are simple motor programs encoded? How are new motor programs or sensory responses learned by the spinal cord? And in the long term, can we use this knowledge to improve recovery for patients with stroke and spinal cord injury? With the mouse as our model system, we are using novel genetic tools, cutting-edge molecular analysis, and sophisticated behavioral analysis to explore the mechanisms of mammalian spinal cord function and plasticity.
Related Scientific Focus Areas
Molecular Biology and Biochemistry
This page was last updated on September 6th, 2017