Anupama Khare, Ph.D.

The overarching goal of our research is to study complex bacterial behaviors and adaptation using genome-scale unbiased approaches, with the ultimate aim of combating microbial infections. Antibiotics have been one of the most critical cornerstones of modern medicine, but resistance to existing antibiotics is rapidly increasing, and very few new antibiotics are currently being developed, raising the possibility of a post-antibiotic era. One approach to developing new antimicrobial therapies is to identify novel genes that are crucial to microbial survival and adaptation in natural environments and pathogenesis, but not necessarily under standard laboratory conditions. Our major research directions are:

Microbial interactions

Microorganisms exist mostly in multispecies communities, and interactions between species can critically affect their fitness and evolutionary trajectories. Most studies on microbial interactions have focused on a single molecule of interest, and its potential effects on other species. However, a multispecies system is likely to consist of several dynamic interactions and understanding such a system requires the identification of the entire breadth of interactions that actually impact fitness of the various species. Our lab aims to identify, characterize, and target the molecular determinants of microbial fitness in diverse communities, including co-infections.

Evolution of antibiotic resistance

Our lab is interested in identifying genetic variation and environmental factors that can affect the frequency and trajectories of the evolution of antibiotic resistance.

Candidates interested in a postdoctoral fellowship or postbaccalaureate training in our lab are encouraged to contact Dr. Khare directly (anupama.khare@nih.gov).

Dr. Anupama Khare received her Ph.D. from Baylor College of Medicine, where she studied mechanisms of cheating and cheater-resistance in the social amoeba Dictyostelium discoideum. She did her postdoctoral research first at Princeton University, and then Columbia University, studying complex microbial behaviors including interspecies interactions, and antibiotic persistence. Her research was supported in part by an NIH Pathway to Independence Award.

Dr. Khare joined the Laboratory of Molecular Biology at the Center for Cancer Research as a Stadtman Tenure Track Investigator in December 2017.