Anthony F. Suffredini, M.D.

Senior Investigator

Critical Care Medicine Department

NIH Clinical Center

Building 10, Room 2C145
10 Center Drive
Bethesda, MD 20892

301-402-3485

asuffredini@mail.nih.gov

Research Topics

Dr. Suffredini's lab group is investigating biomarkers of infection and lung injury. His team is using a novel means of detecting fungal pathogens in bronchoalveolar lavage using proteomic methodology. A major ongoing collaborative project is investigating the effects of inhaled cyclosporine in hematopoietic stem cell or lung transplant patients with bronchiolitis obliterans. Dr. Suffredini directed the development of point-of-care ultrasound in the CCMD ICU and has helped to provide regular didactic and hands-on training for members of the department. He directs the Clinical Center Endotoxin Repository, which for the last 12 years has been the sole world source of endotoxin for human studies. It has provided endotoxin to over fifty different investigators from biopharmaceutical firms, clinical research facilities, and academic centers as a means to study mechanisms of inflammation, proof of principle for evaluation of novel pharmaceutical or biologic agents, and as an immunoadjuvant for immunotherapy trials of cancer.

Biography

Dr. Suffredini completed his undergraduate studies at Boston University. He attended the University of Rome School of Medicine and graduated from the University of Connecticut School of Medicine. He then completed an internship and residency in internal medicine at the Medical College of Virginia, Richmond, and a fellowship in critical care medicine at the University Health Center of Pittsburgh. He served one five-year term as associate editor of the American Journal of Respiratory Diseases and Critical Care. He came to the Clinical Center in 1984 as a medical staff fellow in the Critical Care Medicine Department. He has held his current position as senior investigator since 1989 and is currently associate chief of the department. He is a co-founder of the Functional Genomics Section and Director of the Clinical Proteomics Group in the Critical Care Medicine Department. He is a founding member and serves on the Organizing Committee of the United States Critical Illness and Injury Trials Group (USCIITG).

Selected Publications

  1. Kadri SS, Miller AC, Hohmann S, Bonne S, Nielsen C, Wells C, Gruver C, Quraishi SA, Sun J, Cai R, Morris PE, Freeman BD, Holmes JH, Cairns BA, Suffredini AF, US Critical Illness and Injury Trials Group: Smoke Inhalation-associated Acute Lung Injury (SI-ALI) Investigators (USCIIT-SI-ALI).. Risk Factors for In-Hospital Mortality in Smoke Inhalation-Associated Acute Lung Injury: Data From 68 United States Hospitals. Chest. 2016;150(6):1260-1268.

  2. Wang H, Drake SK, Yong C, Gucek M, Tropea M, Rosenberg AZ, Dekker JP, Suffredini AF. A Novel Peptidomic Approach to Strain Typing of Clinical Acinetobacter baumannii Isolates Using Mass Spectrometry. Clin Chem. 2016;62(6):866-75.

  3. Narute P, Seam N, Tropea M, Logun C, Cai R, Sun J, Shelhamer JH, Meduri GU, Suffredini AF. Temporal Changes in Microrna Expression in Blood Leukocytes from Patients with the Acute Respiratory Distress Syndrome. Shock. 2017;47(6):688-695.

  4. Wang H, Drake SK, Yong C, Gucek M, Lyes MA, Rosenberg AZ, Soderblom E, Arthur Moseley M, Dekker JP, Suffredini AF. A Genoproteomic Approach to Detect Peptide Markers of Bacterial Respiratory Pathogens. Clin Chem. 2017;63(8):1398-1408.

  5. Wang H, Drake SK, Youn JH, Rosenberg AZ, Chen Y, Gucek M, Suffredini AF, Dekker JP. Peptide Markers for Rapid Detection of KPC Carbapenemase by LC-MS/MS. Sci Rep. 2017;7(1):2531.


This page was last updated on September 12th, 2018