Andrew D. Johnson, Ph.D.
Population Sciences Branch
73 MT Wayte Avenue
Framingham, MA 01702
Cardiovascular disease (CVD) has a complex etiology, and CVD patients show a wide range of responses to therapeutic interventions. Dr. Johnson’s laboratory research focuses on understanding genetic and genomic underpinnings of this individual variability in therapeutically targeted CVD pathways. In particular, his work focuses on understanding individual variability in platelet development, function, and response to treatment. Drugs that decrease platelet reactivity, such as aspirin, are commonly used to reduce the risks of cardiovascular events such as myocardial infarction. Dr. Johnson is interested in the pharmacogenetics of anti-platelet treatments and resulting CVD outcomes. His laboratory applies population-scale approaches to the problem including genetic studies, collaboration with clinician-scientists, studies of gene expression variability in human tissues, and bioinformatics and systems biology approaches. His group makes particular use of the Framingham Heart Study and the rich amount of epidemiologic and genetic data it has accumulated over the years.
Additionally, the Johnson laboratory creates and applies cutting edge genomic and bioinformatics resources. To date these resources include SNAP (SNP Annotation and Proxy Search: http://www.broadinstitute.org/mpg/snap/), a fast human linkage disequilibrium query and annotation interface for worldwide population genetic samples; REACHv1 (Reference Annotation Catalog of Human variants), which provides rapid queries of known or novel variants against functional molecular features in the human genome; and GRASP (Genome-wide Repository of Associations between SNPs and Phenotypes), one of the largest and deepest databases of human genetic associations.
In addition to advancing the goals of his research group and others at the NHLBI, these resources will also be made freely available to benefit the wider scientific community, and help advance our understanding of CVD variability.
Andrew Johnson earned a B.S. in vertebrate physiology from the Pennsylvania State University in 1998. He subsequently worked on gene regulatory research in C. elegans and neuroelectrophysiology in rodents before entering graduate school in 2003. He earned a Ph.D. in biomedical sciences from Ohio State University in 2007 with dual emphases in bioinformatics and pharmacogenomics. He came to the NIH for post-doctoral training in 2007 and became a tenure track investigator in 2012. Dr. Johnson has been nominated for and received numerous awards including the NHLBI Lenfant Fellowship, the CHARGE Consortium Early Career Investigator Award and Genome Technology’s Young Investigator Award, and was elected as a Fellow of the American Heart Association. He has published more than 175 papers and has served as a reviewer for more than 40 journals. Dr. Johnson has served on numerous committees of the Framingham Heart Study, and the American Heart Association. He currently chairs the NHLBI TOPMed Hematology and Hemostasis Working Group and the Framingham Heart Study Genetic Steering Committee. He is also a member of the American Society for Human Genetics, the International Society for Computational Biology and the International Society for Thrombosis and Haemostasis.
Eicher JD, Wakabayashi Y, Vitseva O, Esa N, Yang Y, Zhu J, Freedman JE, McManus DD, Johnson AD. Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction. Platelets. 2016;27(3):230-9.
Eicher JD, Chami N, Kacprowski T, Nomura A, Chen MH, Yanek LR, Tajuddin SM, Schick UM, Slater AJ, Pankratz N, Polfus L, Schurmann C, Giri A, Brody JA, Lange LA, Manichaikul A, Hill WD, Pazoki R, Elliot P, Evangelou E, Tzoulaki I, Gao H, Vergnaud AC, Mathias RA, Becker DM, Becker LC, Burt A, Crosslin DR, Lyytikäinen LP, Nikus K, Hernesniemi J, Kähönen M, Raitoharju E, Mononen N, Raitakari OT, Lehtimäki T, Cushman M, Zakai NA, Nickerson DA, Raffield LM, Quarells R, Willer CJ, Peloso GM, Abecasis GR, Liu DJ, Global Lipids Genetics Consortium., Deloukas P, Samani NJ, Schunkert H, Erdmann J, CARDIoGRAM Exome Consortium., Myocardial Infarction Genetics Consortium., Fornage M, Richard M, Tardif JC, Rioux JD, Dube MP, de Denus S, Lu Y, Bottinger EP, Loos RJ, Smith AV, Harris TB, Launer LJ, Gudnason V, Velez Edwards DR, Torstenson ES, Liu Y, Tracy RP, Rotter JI, Rich SS, Highland HM, Boerwinkle E, Li J, Lange E, Wilson JG, Mihailov E, Mägi R, Hirschhorn J, Metspalu A, Esko T, Vacchi-Suzzi C, Nalls MA, Zonderman AB, Evans MK, Engström G, Orho-Melander M, Melander O, O'Donoghue ML, Waterworth DM, Wallentin L, White HD, Floyd JS, Bartz TM, Rice KM, Psaty BM, Starr JM, Liewald DC, Hayward C, Deary IJ, Greinacher A, Völker U, Thiele T, Völzke H, van Rooij FJ, Uitterlinden AG, Franco OH, Dehghan A, Edwards TL, Ganesh SK, Kathiresan S, Faraday N, Auer PL, Reiner AP, Lettre G, Johnson AD. Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals. Am J Hum Genet. 2016;99(1):40-55.
Johnson AD, Yanek LR, Chen MH, Faraday N, Larson MG, Tofler G, Lin SJ, Kraja AT, Province MA, Yang Q, Becker DM, O'Donnell CJ, Becker LC. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. Nat Genet. 2010;42(7):608-13.
Puurunen MK, Hwang SJ, Larson MG, Vasan RS, O'Donnell CJ, Tofler G, Johnson AD. ADP Platelet Hyperreactivity Predicts Cardiovascular Disease in the FHS (Framingham Heart Study). J Am Heart Assoc. 2018;7(5).
Eicher JD, Chen MH, Pitsillides AN, Lin H, Veeraraghavan N, Brody JA, Metcalf GA, Muzny DM, Gibbs RA, Becker DM, Becker LC, Faraday N, Mathias RA, Yanek LR, Boerwinkle E, Cupples LA, Johnson AD. Whole exome sequencing in the Framingham Heart Study identifies rare variation in HYAL2 that influences platelet aggregation. Thromb Haemost. 2017;117(6):1083-1092.
Related Scientific Focus Areas
Genetics and Genomics
This page was last updated on May 7th, 2019