Research Topics
The Mughal Laboratory (The Neurovascular Research Unit) studies neurovascular coupling mechanisms involved in regulation of blood flow in the brain and clearance of metabolic by-products. Along with providing basic understanding of these mechanisms in physiology, the research also extends to the vascular cognitive impairment and dementia (VCID) including stroke and Alzheimer's disease. By using pre-clinical models and cutting-edge imaging approaches, the Mughal laboratory provides a thorough understanding of different neurovascular mechanisms along with the contributions of different vascular compartments (pial arteries-arterioles-capillaries-venules-pial vein) with the aim to extend this knowledge from physiology to disease models.
Biography
Dr. Amreen Mughal obtained her bachelor's and master's degrees in pharmacy from India. After receiving her Ph.D. in Pharmaceutical Sciences from North Dakota State University in 2018, she continued with her postdoctoral work at the University of Vermont in vascular and ion channel physiology. Her postdoctoral work was focused to evaluate mechanisms involved in regulation of blood flow in the brain. Dr. Mughal started her lab at the NIH in 2024. She is a Stadtman Tenure-track Investigator and Chief of the Neurovascular Research Unit in the Stroke branch of the National Institute of Neurological Disorders and Stroke. Her current joint appointment is sponsored by the National Institute of Neurological Disorders and Stroke, and the National Heart, Lung, and Blood Institute.
Selected Publications
- Mughal A, Sackheim AM, Koide M, Bonson G, Ebner G, Hennig G, Lockette W, Nelson MT, Freeman K. Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature. J Cereb Blood Flow Metab. 2024;44(5):680-688.
- Mughal A, Nelson MT, Hill-Eubanks D. The post-arteriole transitional zone: a specialized capillary region that regulates blood flow within the CNS microvasculature. J Physiol. 2023;601(5):889-901.
Related Scientific Focus Areas
Biomedical Engineering and Biophysics
View additional Principal Investigators in Biomedical Engineering and Biophysics
This page was last updated on Friday, November 15, 2024