Amir Hossein Gandjbakhche, Ph.D.

Senior Investigator

Section on Translational Biophotonics


NIHBC 49 - Conte 5A82


Research Topics

Quantitative Biophotonics for Tissue Characterization and Function

Our objectives are to devise quantitative biophotonics methodologies and associated instrumentations in order to study biological phenomena at different length scales—from nanoscopy to microscopy—and diffuse biophotonics. We take advantage of our expertise in stochastic modeling to study complex biological phenomena whose properties are characterized by elements of randomness in both time and space, such as light-tissue interactions. We explore various properties of light-matter interactions as sources of optical contrasts, such as polarization properties, endogenous or exogenous fluorescent labels, absorption (e.g., hemoglobin or chromophore concentration), and/or scattering. We have used these contrast mechanisms for tomographic and spectroscopic methods to develop benchtop instrumentation for preclinical and clinical uses. We are identifying physiological sites where optical techniques might be clinically practical and offer new diagnostic knowledge and/or less morbidity than existing diagnostic methods.


Dr. Amir Gandjbakhche  is a Senior Investigator  and Head of  the Section on Analytical and Functional Biophotonics of NICHD. He obtained his Ph.D. in physics with a biomedical engineering specialty from the University of Paris in 1989.  He is a Fellow of SPIE, the largest society of optical engineers, and Optical Society of America. Dr. Gandjbakhche leads a research group that uses different optical sources of contrast such as endogenous or exogenous fluorescent labels, absorption (e.g., hemoglobin or chromophore concentration) in order to devise quantitative theories at the board, and designs instrumentation at the bench, and brings the imaging system to the bedside.  Areas of interest are the use of near infrared spectroscopy/EEG to applied to developmental disorders and diseases such as cognitive function  in Traumatic Brain Injury and Autistic Spectrum Disorder, and using spectroscopic methods to quantify oxygenation in placenta.

Selected Publications

  1. Condy EE, Miguel HO, Millerhagen J, Harrison D, Khaksari K, Fox N, Gandjbakhche A. Characterizing the Action-Observation Network Through Functional Near-Infrared Spectroscopy: A Review. Front Hum Neurosci. 2021;15:627983.

  2. Khare SM, Nguyen T, Anderson AA, Hill B, Romero R, Gandjbakhche AH. Evaluation of the human placenta optical scattering properties using continuous wave and frequency-domain diffuse reflectance spectroscopy. J Biomed Opt. 2020;25(11).

  3. Khaksari K, Nguyen T, Hill B, Quang T, Perreault J, Gorti V, Malpani R, Blick E, González Cano T, Shadgan B, Gandjbakhche AH. Review of the efficacy of infrared thermography for screening infectious diseases with applications to COVID-19. J Med Imaging (Bellingham). 2021;8(Suppl 1):010901.

  4. Nguyen T, Miguel HO, Condy EE, Park S, Gandjbakhche A. Using Functional Connectivity to Examine the Correlation between Mirror Neuron Network and Autistic Traits in a Typically Developing Sample: A fNIRS Study. Brain Sci. 2021;11(3).

  5. Anderson AA, Gropman A, Le Mons C, Stratakis CA, Gandjbakhche AH. Hemodynamics of Prefrontal Cortex in Ornithine Transcarbamylase Deficiency: A Twin Case Study. Front Neurol. 2020;11:809.

This page was last updated on November 6th, 2020