Amir Hossein Gandjbakhche, Ph.D.
Section on Analytical and Functional Biophotonics
Building 49, Room 5A82
49 Convent Drive
Bethesda, MD 20814
Quantitative Biophotonics for Tissue Characterization and Function
Our objectives are to devise quantitative biophotonics methodologies and associated instrumentations in order to study biological phenomena at different length scales—from nanoscopy to microscopy—and diffuse biophotonics. We take advantage of our expertise in stochastic modeling to study complex biological phenomena whose properties are characterized by elements of randomness in both time and space, such as light-tissue interactions. We explore various properties of light-matter interactions as sources of optical contrasts, such as polarization properties, endogenous or exogenous fluorescent labels, absorption (e.g., hemoglobin or chromophore concentration), and/or scattering. We have used these contrast mechanisms for tomographic and spectroscopic methods to develop benchtop instrumentation for preclinical and clinical uses. We are identifying physiological sites where optical techniques might be clinically practical and offer new diagnostic knowledge and/or less morbidity than existing diagnostic methods.
Dr. Amir Gandjbakhche is a Senior Investigator and Head of the Section on Analytical and Functional Biophotonics of NICHD. He obtained his Ph.D. in physics with a biomedical engineering specialty from the University of Paris in 1989. He is a Fellow of SPIE, the largest society of optical engineers. Dr. Gandjbakhche leads a research group that uses different optical sources of contrast such as endogenous or exogenous fluorescent labels, absorption (e.g., hemoglobin or chromophore concentration) in order to devise quantitative theories at the board, and designs instrumentation at the bench, and brings the imaging system to the bedside. Two areas of interest are the use of near infrared spectroscopy to assess cognitive function in Traumatic Brain Injury and Autistic Spectrum Disorder patients, and using specific fluorescently labeled HER2 imaging agent to monitor monoclonal antibody therapy of breast tumor.
Chernomordik V, Amyot F, Kenney K, Wassermann E, Diaz-Arrastia R, Gandjbakhche A. Abnormality of low frequency cerebral hemodynamics oscillations in TBI population. Brain Res. 2016;1639:194-9.
Afshari A, Ardeshirpour Y, Lodish MB, Gourgari E, Sinaii N, Keil M, Belyavskaya E, Lyssikatos C, Chowdhry FA, Chernomordik V, Anderson AA, Mazzuchi TA, Gandjbakhche A, Stratakis CA. Facial Plethora: Modern Technology for Quantifying an Ancient Clinical Sign and Its Use in Cushing Syndrome. J Clin Endocrinol Metab. 2015;100(10):3928-33.
Karamzadeh N, Ardeshirpour Y, Kellman M, Chowdhry F, Anderson A, Chorlian D, Wegman E, Gandjbakhche A. Relative brain signature: a population-based feature extraction procedure to identify functional biomarkers in the brain of alcoholics. Brain Behav. 2015;5(7):e00335.
Ardeshirpour Y, Chernomordik V, Hassan M, Zielinski R, Capala J, Gandjbakhche A. In vivo fluorescence lifetime imaging for monitoring the efficacy of the cancer treatment. Clin Cancer Res. 2014;20(13):3531-9.