Alison Boyce, MD
Lasker Clinical Research Scholar
Metabolic Bone Disorders Unit
Building 30, Room 228
30 Convent Dr. MSC 4320
Bethesda MD 20892-4320
The mission of the Metabolic Bone Disorders Unit is to enhance health and well-being for children with skeletal disorders by developing novel diagnostic tools and treatments informed by studies of physiologic mechanisms. Our work focuses on rare disorders of bone metabolism, specifically the complex bone and endocrine disorder fibrous dysplasia/McCune-Albright syndrome (FD/MAS). This mosaic disease results from gain-of-function mutations in Gαs, resulting in ligand-independent activation of G-protein coupled receptor/cAMP-dependent signaling pathways. Clinical observations from the care and study of patients with FD/MAS and other skeletal disorders create hypotheses based on unmet needs. Basic and translational studies investigating these hypotheses improve our understanding of skeletal physiology. By integrating across model systems, we apply this knowledge to enhance care and quality of life for patients. This approach has successfully characterized key aspects of FD/MAS pathophysiology, translated into clinical trials, and defined the current standard of patient care.
Dr Boyce completed her pediatric endocrinology fellowship training in the NICHD Program on Developmental Endocrinology and Genetics, and her pediatric residency and medical training at Eastern Virginia Medical School in Norfolk, Virginia. She has held current and previous faculty positions in the NIH Pediatric Endocrinology fellowship training program and Children’s National Hospital. She is active in the patient advocacy community and serves as a Medical Advisor to the FD/MAS Alliance.
Pan KS, Heiss JD, Brown SM, Collins MT, Boyce AM. Chiari I Malformation and Basilar Invagination in Fibrous Dysplasia: Prevalence, Mechanisms, and Clinical Implications. J Bone Miner Res. 2018;33(11):1990-1998.
Boyce AM, Brewer C, DeKlotz TR, Zalewski CK, King KA, Collins MT, Kim HJ. Association of Hearing Loss and Otologic Outcomes With Fibrous Dysplasia. JAMA Otolaryngol Head Neck Surg. 2018;144(2):102-107.
Florenzano P, Pan KS, Brown SM, Paul SM, Kushner H, Guthrie LC, de Castro LF, Collins MT, Boyce AM. Age-Related Changes and Effects of Bisphosphonates on Bone Turnover and Disease Progression in Fibrous Dysplasia of Bone. J Bone Miner Res. 2019;34(4):653-660.
Papadakis GZ, Manikis GC, Karantanas AH, Florenzano P, Bagci U, Marias K, Collins MT, Boyce AM. 18 F-NaF PET/CT IMAGING IN FIBROUS DYSPLASIA OF BONE. J Bone Miner Res. 2019;34(9):1619-1631.
Berglund JA, Tella SH, Tuthill KF, Kim L, Guthrie LC, Paul SM, Stanton R, Collins MT, Boyce AM. Scoliosis in Fibrous Dysplasia/McCune-Albright Syndrome: Factors Associated With Curve Progression and Effects of Bisphosphonates. J Bone Miner Res. 2018;33(9):1641-1648.
Related Scientific Focus Areas
Genetics and Genomics
This page was last updated on August 26th, 2021