Alan Neil Schechter, M.D.
Molecular Medicine Branch
Building 10, Room 9N314B
10 Center Drive
Bethesda, MD 20814
Studying the interaction of blood, especially red cells and hemoglobin, with the recently discovered signaling molecule nitric oxide (NO) should provide new information about normal and abnormal physiology and potential pharmacology.
Our research program is currently focused on the interaction of NO and hemoglobin, with the goal of understanding how NO may be transported by blood and thus act at distal sites, opening up its use as a pharmacological agent. This work has the potential for developing therapies for a variety of ischemic diseases, as well as sickle cell anemia and related hemoglobinopathies in which blood flow is impaired. Other research projects currently underway involve studies of the pathophysiological role of cell-free hemoglobin, cell signaling in the NO pathway, and the effects of nitrite/NO on platelet function.
Applying our Research
This research may give us clues regarding how to develop new therapies for several common diseases, as well as improve our understanding and treatment of the genetic anemias.
Need for Further Study
The control of blood flow in human beings, both normally and in disease states, requires further study.
- Special Research Fellow, NIAMS, NIH, 1967-1969
- Research Associate, NIAMS, NIH, 1965-1967
- Resident, Albert Einstein Medical College, 1963-1965
- M.D., Columbia University, 1963
- B.A., Cornell University, 1959
Čokić VP, Smith RD, Biancotto A, Noguchi CT, Puri RK, Schechter AN. Globin gene expression in correlation with G protein-related genes during erythroid differentiation. BMC Genomics. 2013;14:116.
Park JW, Piknova B, Huang PL, Noguchi CT, Schechter AN. Effect of blood nitrite and nitrate levels on murine platelet function. PLoS One. 2013;8(2):e55699.
Park JW, Piknova B, Nghiem K, Lozier JN, Schechter AN. Inhibitory effect of nitrite on coagulation processes demonstrated by thrombelastography. Nitric Oxide. 2014;40:45-51.
Tiso M, Schechter AN. Nitrate reduction to nitrite, nitric oxide and ammonia by gut bacteria under physiological conditions. PLoS One. 2015;10(3):e0119712.
Piknova B, Park JW, Swanson KM, Dey S, Noguchi CT, Schechter AN. Skeletal muscle as an endogenous nitrate reservoir. Nitric Oxide. 2015;47:10-16.