Alan P. Koretsky, Ph.D.
Laboratory of Functional and Molecular Imaging
Building 10, Room B1D728
10 Center Drive
Bethesda, MD 20892-1065
The Functional and Molecular Imaging Section has two major research interests. One is to develop novel functional and molecular imaging techniques to study brain structure and function. Emphasis is on MRI but some optical imaging is performed as well. Current areas of interest are to extend spatial resolution and understand the relation of functional MRI to neuronal architecture. New imaging tools are being developed to image calcium influx and gene expression non-invasively in the mouse brain.
The second major research area is cellular energetics. In particular, we are interested in the role of the enzyme creatine kinase and regulation of mitochondrial metabolism. This work relies on combining non-invasive imaging tools and molecular genetics in the mouse to study mitochondrial function in vivo. Current areas of interest are to determine the role of creatine kinase in cell growth and death. We are also interested in characterizing changes in the mitochondrial proteome during changes in mitochondrial metabolism using novel two-dimensional gel electrophoresis techniques.
Saar G, Millo CM, Szajek LP, Bacon J, Herscovitch P, Koretsky AP. Anatomy, Functionality, and Neuronal Connectivity with Manganese Radiotracers for Positron Emission Tomography. Mol Imaging Biol. 2018;20(4):562-574.
Chung S, Jeong JH, Ko S, Yu X, Kim YH, Isaac JTR, Koretsky AP. Peripheral Sensory Deprivation Restores Critical-Period-like Plasticity to Adult Somatosensory Thalamocortical Inputs. Cell Rep. 2017;19(13):2707-2717.
Pothayee N, Cummings DM, Schoenfeld TJ, Dodd S, Cameron HA, Belluscio L, Koretsky AP. Magnetic resonance imaging of odorant activity-dependent migration of neural precursor cells and olfactory bulb growth. Neuroimage. 2017;158:232-241.
Yu X, He Y, Wang M, Merkle H, Dodd SJ, Silva AC, Koretsky AP. Sensory and optogenetically driven single-vessel fMRI. Nat Methods. 2016;13(4):337-40.
Zabow G, Dodd SJ, Koretsky AP. Shape-changing magnetic assemblies as high-sensitivity NMR-readable nanoprobes. Nature. 2015;520(7545):73-7.
Related Scientific Focus Areas
Biomedical Engineering and Biophysics
This page was last updated on September 10th, 2018