Alan P. Koretsky, Ph.D.

Senior Investigator

Laboratory of Functional and Molecular Imaging

NINDS

Building 10, Room B1D728
10 Center Drive
Bethesda, MD 20892-1065

301-402-9659

koretskya@ninds.nih.gov

Research Topics

The Functional and Molecular Imaging Section has two major research interests. One is to develop novel functional and molecular imaging techniques to study brain structure and function. Emphasis is on MRI but some optical imaging is performed as well. Current areas of interest are to extend spatial resolution and understand the relation of functional MRI to neuronal architecture. New imaging tools are being developed to image calcium influx and gene expression non-invasively in the mouse brain.

The second major research area is cellular energetics. In particular, we are interested in the role of the enzyme creatine kinase and regulation of mitochondrial metabolism. This work relies on combining non-invasive imaging tools and molecular genetics in the mouse to study mitochondrial function in vivo. Current areas of interest are to determine the role of creatine kinase in cell growth and death. We are also interested in characterizing changes in the mitochondrial proteome during changes in mitochondrial metabolism using novel two-dimensional gel electrophoresis techniques.

Biography

Dr. Koretsky received his B.S. degree from the Massachusetts Institute of Technology and Ph.D. from the University of California at Berkeley. He performed postdoctoral work in the NHLBI at NIH studying regulation of mitochondrial metabolism using optical and NMR techniques. Dr. Koretsky spent twelve years on the faculty in the Department of Biological Sciences at Carnegie Mellon University where he was the Eberly Professor of Structural Biology and Chemistry. In summer 1999, he moved to NINDS as Chief of the Laboratory of Functional and Molecular Imaging and Director of the NIH MRI Research Facility. Dr. Koretsky's laboratory is interested in two main areas. They are actively developing novel imaging techniques to visualize brain function and study the regulation of cellular energy metabolism combining molecular genetics with non-invasive imaging tools. Dr. Koretsky interview in Oral History Program : https://history.nih.gov/archives/downloads/alankoretsky.pdf

Selected Publications

  1. Petrus E, Saar G, Ma Z, Dodd S, Isaac JTR, Koretsky AP. Interhemispheric plasticity is mediated by maximal potentiation of callosal inputs. Proc Natl Acad Sci U S A. 2019;116(13):6391-6396.

  2. Pothayee N, Maric D, Sharer K, Tao-Cheng JH, Calac A, Bouraoud N, Pickel J, Dodd S, Koretsky A. Neural precursor cells form integrated brain-like tissue when implanted into rat cerebrospinal fluid. Commun Biol. 2018;1:114.

  3. Barbic M, Dodd SJ, Morris HD, Dilley N, Marcheschi B, Huston A, Harris TD, Koretsky AP. Magnetocaloric materials as switchable high contrast ratio MRI labels. Magn Reson Med. 2019;81(4):2238-2246.

  4. Saar G, Koretsky AP. Manganese Enhanced MRI for Use in Studying Neurodegenerative Diseases. Front Neural Circuits. 2018;12:114.

  5. Sudarshana DM, Nair G, Dwyer JT, Dewey B, Steele SU, Suto DJ, Wu T, Berkowitz BA, Koretsky AP, Cortese ICM, Reich DS. Manganese-Enhanced MRI of the Brain in Healthy Volunteers. AJNR Am J Neuroradiol. 2019;40(8):1309-1316.


This page was last updated on January 23rd, 2018