A big part of the NIH IRP’s success in pushing biomedical science forward involves shared access to state-of-the-art facilities and resources. By combining forces, Intramural investigators and technical experts find new ways to answer research questions that no single person could accomplish alone.
The following is a short list of the resources available to all IRP teams, and additional resources are shared among some Institutes and Centers.
BEPS provides IRP scientists with access to microanalytical immunochemistry, microfabrication and microfluidics, transmission and scanning electron microscopy (including serial block-face imaging), scanning probe microscopy, quantitative methods for molecular interactions, and clinical/basic infrared imaging. Learn more about BEPS in the NIH Catalyst newsletter article.
Contact: Henry Eden, Chief
DSEIS provides laboratory equipment sales, rental, repairs, and maintenance to IRP scientists. These services include acquisition of laboratory equipment through a rental, a rent-to-buy, or a purchase agreement. Our services include custom instrumentation, equipment design, fabrication, and modification; equipment installation, testing, refurbishing, and calibration; evaluation of laboratory equipment, their maintenance requirements, and current or proposed contracts.
DVR is the central animal care program that provides research collaboration through housing, veterinary care, technical support, animal transportation and procurement, surgery/ICU/pharmacy, diagnostics (pathology), mouse phenotyping, behavior consultation, animal training, nutrition consultation, and other services.
Contact: Charmaine Foltz, Director
IPDC provides IRP scientists with targeted imaging probes that help accelerate cell based assays, in vivo imaging studies, and translational research leading to better disease diagnosis. It comprises a core synthesis facility dedicated to the preparation of imaging probes, including radiolabeling for PET and SPECT applications, and a research component dedicated to the discovery of new imaging approaches and compositions.
Contact: Rolf Swenson, Director
The Natural Products Repository serves as a national resource for IRP scientists looking to acquire plants and marine organisms for their research. Extracts from the repository are available either in vials or in 96-well plates through the Open Repository Program and the Active Repository Program.
Contact: David Newman, Natural Products Branch Chief
NISC is a multidisciplinary genomics facility that emphasizes the generation and analysis of DNA sequences. In addition to providing IRP investigators with access to well-established, high-throughput DNA sequencing, NISC works closely with NIH collaborators to explore the use and implementation of leading edge genomics technologies, molecular biology protocols, and analytical procedures.
Contact: Jim Mullikin, Director
The PET Department at the NIH Clinical Center has three PET scanners dedicated to clinical research. In addition, the facility has three medical cyclotrons and 10 hot cells to produce a wide variety of positron-emitting radiopharmaceuticals. A new cGMP Facility for production of radiopharmaceuticals will soon be put into operation. The department is staffed by a dedicated team of cyclotron engineers, radiochemists, healthcare providers, and scientists.
Contact: Peter Herscovitch, M.D., Director
The Trans-NIH RNAi Initiative provides IRP scientists with high-throughput RNAi screening services. The facility assists with all stages of projects ranging from assay development through genome-wide siRNA screens, informatics/pathway analysis, rigorous follow-up, and confirmatory/mechanistic assays. Genome-wide siRNA screens for both human and mouse are conducted, and miRNA mimic and inhibitor libraries are routinely included in screens.
Contact: Scott Martin, Group Leader, RNAi Screening
The Zebrafish Core’s goal is to help researchers perform zebrafish experiments aimed at illuminating basic biology and human disease mechanisms, thereby advancing the IRP’s research mission. The core is equipped to assist in gene expression and regulation studies, gain of gene function studies, and loss of gene function studies.
Contact: Benjamin Feldman, Director
For Internal Use
MIF is a shared intramural resource for animal imaging studies. MIF was established to provide the NIH intramural community access to modern radiological imaging methods optimized for studying mice and other research animals, and to advance the state-of-the-art in small animal imaging.
Contact: Brenda Klaunberg, Animal Imaging Program Director
NMRF is a shared Intramural resource for human magnetic resonance imaging (MRI) studies. NMRF provides intellectual, technical and material support for investigators using its imaging and computer resources. NMRF includes a state-of-the-art 3.0 T human MRI system, accessories for anatomical and functional MRI studies, and patient preparation rooms.
Contact: Lalith Talagala, Technical Director