Weight loss leads to strong increase in appetite

Friday, October 14, 2016

Study with diabetes drug measures how extra calories caused weight loss plateau.

Analysis of a trial that used the drug canagliflozin found that as people lost weight, their appetite increased proportionately, leading to consumption of more calories and weight loss plateau (leveling off). The findings provide the first measurement in people of how strongly appetite counters weight loss as part of the body’s feedback control system regulating weight. Results are currently available on BioRxiv and will publish in Obesity during Obesity Week 2016.